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ebgR DNA-binding transcriptional repressor EbgR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947586, updated on 3-Dec-2024

Summary

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Official Symbol
ebgR
Official Full Name
DNA-binding transcriptional repressor EbgR
Primary source
ECOCYC:EG10254
Locus tag
b3075
See related
ASAP:ABE-0010099
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3065
Summary
Wildtype EbgR is inducible by lactose, although this is probably not the natural inducer. [More information is available at EcoGene: EG10254]. EbgR (for "evolved -galactosidase repressor") negatively regulates genes involved in the evolved -galactosidase system, which constitutes an alternative for lactose utilization in cells with mutations on the lacZ gene . [More information is available at EcoCyc: EG10254].
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Genomic context

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Sequence:
NC_000913.3 (3221466..3222449)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putrescine aminotransferase Neighboring gene putative tRNA-binding protein YgjH Neighboring gene evolved beta-D-galactosidase subunit alpha Neighboring gene DUF386 domain-containing evolved beta-D-galactosidase subunit beta Neighboring gene putative transporter YgjI

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of newly evolved enzymes. II. The ebg repressor. Gall BG, et al. Genetics, 1975 Nov. PMID 1107144, Free PMC Article
  2. Regulation of newly evolved enzymes. III Evolution of the ebg repressor during selection for enhanced lactase activity. Hall BG, et al. Genetics, 1977 Feb. PMID 324865, Free PMC Article
  3. Isolation and characterization of the newly evolved ebg beta-galactosidase of Escherichia coli K-12. Arraj JA, et al. J Bacteriol, 1975 Nov. PMID 241745, Free PMC Article
  4. Regulation of newly evolved enzymes. IV. Directed evolution of the Ebg repressor. Hall BG. Genetics, 1978 Dec. PMID 105963, Free PMC Article
  5. Evolution of a regulated operon in the laboratory. Hall BG. Genetics, 1982 Jul-Aug. PMID 6816666, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional repressor EbgR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3221466..3222449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417546.1 DNA-binding transcriptional repressor EbgR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417546.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8NC48
    Conserved Domains (1) summary
    PRK10339
    Location:1 → 327
    PRK10339; DNA-binding transcriptional repressor EbgR; Provisional
Nucleotide Protein
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