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garL alpha-dehydro-beta-deoxy-D-glucarate aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947630, updated on 3-Dec-2024

Summary

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Official Symbol
garL
Official Full Name
alpha-dehydro-beta-deoxy-D-glucarate aldolase
Primary source
ECOCYC:EG10016
Locus tag
b3126
See related
ASAP:ABE-0010276
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3114; yhaF
Summary
dehydro--deoxy-D-glucarate aldolase cleaves both 5-dehydro-4-deoxy- and 2-dehydro-3-deoxy-D-glucarate, thereby continuing the catabolism of D-glucarate and D-galactarate . [More information is available at EcoCyc: EG10016].
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Genomic context

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Sequence:
NC_000913.3 (3272787..3273557, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycerate 2-kinase 1 Neighboring gene tartronate semialdehyde reductase Neighboring gene galactarate/D-glucarate transporter GarP Neighboring gene GarD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rhombohedral crystals of 2-dehydro-3-deoxygalactarate aldolase from Escherichia coli. Blackwell NC, et al. Acta Crystallogr D Biol Crystallogr, 1999 Jul. PMID 10393309
  2. Two genes affecting glucarate utilization in Escherichia coli K12. Roberton AM, et al. J Gen Microbiol, 1980 Apr. PMID 6999115
  3. Precise mapping of the rnpB gene encoding the RNA component of RNase P in Escherichia coli K-12. Komine Y, et al. J Bacteriol, 1991 Mar. PMID 1705543, Free PMC Article
  4. Processing of the precursor to the catalytic RNA subunit of RNase P from Escherichia coli. Lundberg U, et al. RNA, 1995 May. PMID 7489504, Free PMC Article
  5. Crystal structures of the metal-dependent 2-dehydro-3-deoxy-galactarate aldolase suggest a novel reaction mechanism. Izard T, et al. EMBO J, 2000 Aug 1. PMID 10921867, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-dehydro-3-deoxy-D-gluconate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-dehydro-3-deoxyglucarate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-dehydro-3-deoxyglucarate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbon-carbon lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within D-glucarate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in D-glucarate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within galactarate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in galactarate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glucarate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glucarate catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha-dehydro-beta-deoxy-D-glucarate aldolase
NP_417595.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3272787..3273557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417595.1 alpha-dehydro-beta-deoxy-D-glucarate aldolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417595.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376WX81, A0A6M9X3F9
    Conserved Domains (1) summary
    PRK10558
    Location:1 → 256
    PRK10558; alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional
Nucleotide Protein
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