U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

garD GarD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947641, updated on 17-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
garD
Official Full Name
GarD
Primary source
ECOCYC:EG12522
Locus tag
b3128
See related
ASAP:ABE-0010284
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3116; yhaG
Summary
Galactarate dehydratase catalyzes the dehydration of galactarate, the naturally occurring dicarboxylic acid analogue of D-galactose . [More information is available at EcoCyc: EG12522].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (3275282..3276853)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene alpha-dehydro-beta-deoxy-D-glucarate aldolase Neighboring gene galactarate/D-glucarate transporter GarP Neighboring gene antitoxin PrlF Neighboring gene ribosome-dependent mRNA interferase toxin YhaV Neighboring gene DNA-binding transcriptional repressor AgaR

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Asymmetric dehydration of galactarate by bacterial galactarate dehydratase. Blumenthal HJ, et al. Biochem Biophys Res Commun, 1964 Oct 14. PMID 4285952
  2. Identification, cloning, and characterization of the Escherichia coli sohA gene, a suppressor of the htrA (degP) null phenotype. Baird L, et al. J Bacteriol, 1990 Mar. PMID 2407727, Free PMC Article
  3. Structure of galactarate dehydratase, a new fold in an enolase involved in bacterial fitness after antibiotic treatment. Rosas-Lemus M, et al. Protein Sci, 2020 Mar. PMID 31811683, Free PMC Article
  4. A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate utilization in Escherichia coli. Monterrubio R, et al. J Bacteriol, 2000 May. PMID 10762278, Free PMC Article
  5. Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli. Hubbard BK, et al. Biochemistry, 1998 Oct 13. PMID 9772162

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ferrous iron binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactarate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactarate dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables galactarate dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-galacturonate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactarate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within galactarate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in galactarate catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
GarD
NP_417597.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3275282..3276853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417597.1 GarD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417597.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1NWC9
    Conserved Domains (1) summary
    TIGR03248
    Location:15 → 523
    galactar-dH20; galactarate dehydratase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.