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mtgA peptidoglycan glycosyltransferase MtgA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947728, updated on 17-Dec-2024

Summary

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Official Symbol
mtgA
Official Full Name
peptidoglycan glycosyltransferase MtgA
Primary source
ECOCYC:G7668
Locus tag
b3208
See related
ASAP:ABE-0010530
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3197; mgt; yrbM
Summary
MtgA has flavomycin-resistant peptidoglycan synthesis activity (Di Berardino, 1996; Derouaux, 2007). mtgA is a non-essential gene (Schiffer, 1999). [More information is available at EcoGene: EG12808]. MtgA is a monofunctional peptidoglycan transglycosylase involved in polymerization of lipid II molecules into glycan strands of peptidoglycan. [More information is available at EcoCyc: G7668].
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Genomic context

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Sequence:
NC_000913.3 (3349081..3349809, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phosphotransferase system enzyme IIA(Ntr) Neighboring gene RNase adaptor protein RapZ Neighboring gene phosphorelay protein NPr Neighboring gene protein kinase-like domain-containing protein YrbL Neighboring gene low activity glyoxalase ElbB Neighboring gene ncRNA Neighboring gene sensor histidine kinase ArcB Neighboring gene radical SAM family oxidoreductase YhcC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Killing by ampicillin and ofloxacin induces overlapping changes in Escherichia coli transcription profile. Kaldalu N, et al. Antimicrob Agents Chemother, 2004 Mar. PMID 14982780, Free PMC Article
  2. The monofunctional glycosyltransferase of Escherichia coli is a member of a new class of peptidoglycan-synthesising enzymes. Di Berardino M, et al. FEBS Lett, 1996 Aug 26. PMID 8772200
  3. A novel glycan polymerase that synthesizes uncross-linked peptidoglycan in Escherichia coli. Hara H, et al. FEBS Lett, 1984 Mar 12. PMID 6368264
  4. The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN. Derouaux A, et al. J Bacteriol, 2008 Mar. PMID 18165305, Free PMC Article
  5. Genomic changes arising in long-term stab cultures of Escherichia coli. Faure D, et al. J Bacteriol, 2004 Oct. PMID 15375124, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that MtgA localizes at the division site of Escherichia coli cells that are deficient in PBP1b and produce a thermosensitive PBP1a and is able to interact with three constituents of the divisome, PBP3, FtsW, and FtsN.
    Title: The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pentosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidoglycan glycosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Gram-negative-bacterium-type cell wall biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peptidoglycan-based cell wall IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
peptidoglycan glycosyltransferase MtgA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3349081..3349809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417675.1 peptidoglycan glycosyltransferase MtgA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417675.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2H4TUH9
    Conserved Domains (1) summary
    PRK00056
    Location:5 → 239
    mtgA; monofunctional biosynthetic peptidoglycan transglycosylase; Provisional
Nucleotide Protein
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