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nuoM NADH:quinone oxidoreductase subunit M [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947731, updated on 3-Dec-2024

Summary

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Official Symbol
nuoM
Official Full Name
NADH:quinone oxidoreductase subunit M
Primary source
ECOCYC:EG11773
Locus tag
b2277
See related
ASAP:ABE-0007529
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2271; nuoA
Summary
NuoM and NuoL are located at the distal end of the membrane arm. the redox centers are in the peripheral arm. [More information is available at EcoGene: EG11773]. NuoM is part of the inner membrane component of NADH dehydrogenase I . [More information is available at EcoCyc: EG11773].
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Genomic context

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Sequence:
NC_000913.3 (2391512..2393041, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YfbP Neighboring gene NADH:quinone oxidoreductase subunit N Neighboring gene NADH:quinone oxidoreductase subunit L Neighboring gene NADH:quinone oxidoreductase subunit K Neighboring gene NADH:quinone oxidoreductase subunit J

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Features of subunit NuoM (ND4) in Escherichia coli NDH-1: TOPOLOGY AND IMPLICATION OF CONSERVED GLU144 FOR COUPLING SITE 1. Torres-Bacete J, et al. J Biol Chem, 2009 Nov 27. PMID 19815558, Free PMC Article
  2. Single particle analysis confirms distal location of subunits NuoL and NuoM in Escherichia coli complex I. Baranova EA, et al. J Struct Biol, 2007 Aug. PMID 17360196
  3. The transmembrane helices of the L, M, and N subunits of Complex I from E. coli can be assigned on the basis of conservation and hydrophobic moment analysis. Vik SB. FEBS Lett, 2011 Apr 20. PMID 21420404
  4. Mutagenesis of the L, M, and N subunits of Complex I from Escherichia coli indicates a common role in function. Michel J, et al. PLoS One, 2011 Feb 28. PMID 21387012, Free PMC Article
  5. A requirement for anaerobically induced redox functions during aerobic growth of Escherichia coli with serine, glycine and leucine as carbon source. Lan J, et al. Res Microbiol, 2003 Apr. PMID 12706508

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. To explore the functional relevance of the pseudosymmetric inverted-repeat structures of the antiporter-like subunits NuoL/M/N, we constructed a symmetry-related structure of a possible alternate-access state.
    Title: Electrostatics, hydration, and proton transfer dynamics in the membrane domain of respiratory complex I.
  2. Mutagenesis of the L, M, and N subunits of Complex I from Escherichia coli indicates a common role in function.
    Title: Mutagenesis of the L, M, and N subunits of Complex I from Escherichia coli indicates a common role in function.
  3. Data show that in L, M, and N subunits of Complex I, transmembrane helices 9 and 12 are predicted to form the discontinuous helices, which are likely to play a key role in function.
    Title: The transmembrane helices of the L, M, and N subunits of Complex I from E. coli can be assigned on the basis of conservation and hydrophobic moment analysis.
  4. Data show that none of the mutants showed alteration in the detectable levels of expressed NuoM or on the NDH-1 assembly.
    Title: Features of subunit NuoM (ND4) in Escherichia coli NDH-1: TOPOLOGY AND IMPLICATION OF CONSERVED GLU144 FOR COUPLING SITE 1.
  5. Data show that subunits NuoL and M jointly occupy a distal half of the membrane domain of respiratory complex I, separated by about 10nm from the interface with the peripheral arm.
    Title: Single particle analysis confirms distal location of subunits NuoL and NuoM in Escherichia coli complex I.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
contributes_to NADH dehydrogenase (ubiquinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to NADH dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to NADH dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquinone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquinone binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP synthesis coupled electron transport IEA
Inferred from Electronic Annotation
more info
  
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in electron transport coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in electron transport coupled proton transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in respiratory electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of NADH dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of respiratory chain complex I NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
NADH:quinone oxidoreductase subunit M
NP_416780.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2391512..2393041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416780.1 NADH:quinone oxidoreductase subunit M [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416780.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7JR71
    Conserved Domains (1) summary
    PRK05846
    Location:1 → 509
    PRK05846; NADH:ubiquinone oxidoreductase subunit M; Reviewed
Nucleotide Protein
Heading Accession and Version

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