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mreD cell shape determining protein MreD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947756, updated on 3-Dec-2024

Summary

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Official Symbol
mreD
Official Full Name
cell shape determining protein MreD
Primary source
ECOCYC:EG10610
Locus tag
b3249
See related
ASAP:ABE-0010656
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3237
Summary
[More information is available at EcoGene: EG10610]. The mre genes are responsible for rod shape and mecillinam sensitivity in Escherichia coli . [More information is available at EcoCyc: EG10610].
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Genomic context

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Sequence:
NC_000913.3 (3398387..3398875, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phospholipid transport factor YhdP Neighboring gene RNase G Neighboring gene nucleoside triphosphate pyrophosphatase YhdE Neighboring gene cell shape determining protein MreC Neighboring gene dynamic cytoskeletal protein MreB Neighboring gene regulator of CsrB and CsrC decay

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Formate auxotroph of Methanobacterium thermoautotrophicum Marburg. Tanner RS, et al. J Bacteriol, 1989 Dec. PMID 2687241, Free PMC Article
  2. Sec- and Tat-dependent translocation of beta-lactamases across the Escherichia coli inner membrane. Pradel N, et al. Antimicrob Agents Chemother, 2009 Jan. PMID 18981261, Free PMC Article
  3. Cell shape determination in Escherichia coli. Osborn MJ, et al. Curr Opin Microbiol, 2007 Dec. PMID 17981077
  4. Duplication and segregation of the actin (MreB) cytoskeleton during the prokaryotic cell cycle. Vats P, et al. Proc Natl Acad Sci U S A, 2007 Nov 6. PMID 17978175, Free PMC Article
  5. Transcriptional analysis of the Escherichia coli mreBCD genes responsible for morphogenesis and chromosome segregation. Wachi M, et al. Biosci Biotechnol Biochem, 2006 Nov. PMID 17090951

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA.
    Title: MreC and MreD balance the interaction between the elongasome proteins PBP2 and RodA.
  2. Cells lacking mreD were fully viable and propagated as small spheres under conditions of slow mass increase but formed large nondividing spheroids with noncanonical FtsZ assembly patterns at higher mass doubling rates.
    Title: Conditional lethality, division defects, membrane involution, and endocytosis in mre and mrd shape mutants of Escherichia coli.
  3. We found that cells depleted of mreBCD became spherical, enlarged and finally lysed. Depletion of each mre gene separately conferred similar gross changes in cell morphology and viability.
    Title: The morphogenetic MreBCD proteins of Escherichia coli form an essential membrane-bound complex.
  4. three promoters contributed to the expression of mreBCD
    Title: Transcriptional analysis of the Escherichia coli mreBCD genes responsible for morphogenesis and chromosome segregation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidoglycan biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within regulation of cell shape EXP
Inferred from Experiment
more info
 PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cell shape determining protein MreD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3398387..3398875 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417715.1 cell shape determining protein MreD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417715.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9APZ2
    Conserved Domains (1) summary
    PRK11060
    Location:1 → 162
    PRK11060; rod shape-determining protein MreD; Provisional
Nucleotide Protein
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