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aaeR DNA-binding transcriptional activator AaeR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947760, updated on 3-Dec-2024

Summary

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Official Symbol
aaeR
Official Full Name
DNA-binding transcriptional activator AaeR
Primary source
ECOCYC:G7688
Locus tag
b3243
See related
ASAP:ABE-0010639
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3232; qseA; yhcS
Summary
LysR family. [More information is available at EcoGene: EG12825]. Mutation and gene fusion studies have shown that AaeR is a positive transcription factor for the divergently transcribed aaeXAB operon and is required for upregulation of expression of aaeXAB in response to some hydroxylated and nonhydroxylated, aromatic carboxylic acids such as p-hyroxybenzoic acid (pHBA), salicylate, benzoate, and 1-naphthoate. [More information is available at EcoCyc: G7688].
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Genomic context

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Sequence:
NC_000913.3 (3389520..3390449)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene aromatic carboxylic acid efflux pump membrane fusion protein Neighboring gene DUF1656 domain-containing protein AaeX Neighboring gene metalloprotease subunit TldD Neighboring gene phospholipid transport factor YhdP

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Quorum-sensing Escherichia coli regulator A: a regulator of the LysR family involved in the regulation of the locus of enterocyte effacement pathogenicity island in enterohemorrhagic E. coli. Sperandio V, et al. Infect Immun, 2002 Jun. PMID 12011002, Free PMC Article
  2. The repertoire of DNA-binding transcriptional regulators in Escherichia coli K-12. Pérez-Rueda E, et al. Nucleic Acids Res, 2000 Apr 15. PMID 10734204, Free PMC Article
  3. Phylogenetic distribution of DNA-binding transcription factors in bacteria and archaea. Pérez-Rueda E, et al. Comput Biol Chem, 2004 Dec. PMID 15556475
  4. Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve? Van Dyk TK, et al. J Bacteriol, 2004 Nov. PMID 15489430, Free PMC Article
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within DNA-templated transcription RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
acts_upstream_of_or_within DNA-templated transcription initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional activator AaeR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3389520..3390449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417710.1 DNA-binding transcriptional activator AaeR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417710.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376M380, A0A772W1B1
    Conserved Domains (1) summary
    PRK10632
    Location:1 → 309
    PRK10632; HTH-type transcriptional activator AaeR
Nucleotide Protein
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