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acrF multidrug efflux pump RND permease AcrF [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947768, updated on 3-Dec-2024

Summary

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Official Symbol
acrF
Official Full Name
multidrug efflux pump RND permease AcrF
Primary source
ECOCYC:EG10267
Locus tag
b3266
See related
ASAP:ABE-0010724
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3253; envD
Summary
AcrEF confers resistance to nalidixic acid, acriflavin, indole and solvents. [More information is available at EcoGene: EG10267]. AcrEF is a multidrug efflux system in Escherichia coli that is highly homologous to the AcrAB multidrug efflux system . [More information is available at EcoCyc: EG10267].
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Genomic context

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Sequence:
NC_000913.3 (3415033..3418137)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor EnvR Neighboring gene multidrug efflux pump membrane fusion lipoprotein AcrE Neighboring gene lipoprotein YhdV Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Locations of the envCD genes on the physical map of the Escherichia coli chromosome. Klein JR, et al. J Bacteriol, 1992 Jun. PMID 1592834, Free PMC Article
  2. Role of multiple efflux pumps in Escherichia coli in indole expulsion. Kawamura-Sato K, et al. FEMS Microbiol Lett, 1999 Oct 15. PMID 10518736
  3. Multidrug resistance pumps in bacteria: variations on a theme. Lewis K. Trends Biochem Sci, 1994 Mar. PMID 8203018
  4. Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC. Lau SY, et al. J Bacteriol, 2005 Nov. PMID 16267305, Free PMC Article
  5. Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps. Bohnert JA, et al. Antimicrob Agents Chemother, 2005 Feb. PMID 15673787, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane EXP
Inferred from Experiment
more info
 PubMed 
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of efflux pump complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
multidrug efflux pump RND permease AcrF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3415033..3418137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417732.1 multidrug efflux pump RND permease AcrF [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417732.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN3IP00
    Conserved Domains (1) summary
    TIGR00915
    Location:1 → 1034
    2A0602; The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family
Nucleotide Protein
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