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igaA inner membrane protein IgaA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947905, updated on 3-Dec-2024

Summary

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Official Symbol
igaA
Official Full Name
inner membrane protein IgaA
Primary source
ECOCYC:G7741
Locus tag
b3398
See related
ASAP:ABE-0011090
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3385; yrfF
Summary
YrfF is orthologous to Salmonella intracellular growth attenuator protein IgaA (YrfF)(S.t.), and homologous to UmoB(P.m.) which upregulates flhDC in P. mirabilis. [More information is available at EcoGene: EG12927]. An mrcA nudE yrfF triple mutant exhibits phenotypes including mucoidy, heat sensitivity, growth defects, and resistance to phage or antibiotic drugs, whereas a single mrcA mutant does not . [More information is available at EcoCyc: G7741].
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Genomic context

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Sequence:
NC_000913.3 (3526469..3528604)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene peptidoglycan glycosyltransferase/peptidoglycan DD-transpeptidase MrcA Neighboring gene ADP-sugar diphosphatase NudE Neighboring gene purine nucleotidase Neighboring gene heat shock protein Hsp15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Conformational rearrangements in the sensory RcsF/OMP complex mediate signal transduction across the bacterial cell envelope. Lach SR, et al. PLoS Genet, 2023 Jan. PMID 36706155, Free PMC Article
  2. IgaA negatively regulates the Rcs Phosphorelay via contact with the RcsD Phosphotransfer Protein. Wall EA, et al. PLoS Genet, 2020 Jul. PMID 32716926, Free PMC Article
  3. Instability of the Salmonella RcsCDB signalling system in the absence of the attenuator IgaA. Mariscotti JF, et al. Microbiology (Reading), 2008 May. PMID 18451046
  4. Repression of the RcsC-YojN-RcsB phosphorelay by the IgaA protein is a requisite for Salmonella virulence. Domínguez-Bernal G, et al. Mol Microbiol, 2004 Sep. PMID 15387821
  5. Reconstruction of Escherichia coli mrcA (PBP 1a) mutants lacking multiple combinations of penicillin binding proteins. Meberg BM, et al. J Bacteriol, 2001 Oct. PMID 11567017, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conformational rearrangements in the sensory RcsF/OMP complex mediate signal transduction across the bacterial cell envelope.
    Title: Conformational rearrangements in the sensory RcsF/OMP complex mediate signal transduction across the bacterial cell envelope.
  2. IgaA negatively regulates the Rcs Phosphorelay via contact with the RcsD Phosphotransfer Protein.
    Title: IgaA negatively regulates the Rcs Phosphorelay via contact with the RcsD Phosphotransfer Protein.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
inner membrane protein IgaA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3526469..3528604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417857.1 inner membrane protein IgaA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417857.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2H4TU30
    Conserved Domains (1) summary
    pfam07095
    Location:19 → 705
    IgaA; Intracellular growth attenuator protein IgaA
Nucleotide Protein
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