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yhhW quercetin 2,3-dioxygenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947945, updated on 17-Dec-2024

Summary

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Official Symbol
yhhW
Official Full Name
quercetin 2,3-dioxygenase
Primary source
ECOCYC:G7756
Locus tag
b3439
See related
ASAP:ABE-0011228
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3424
Summary
YhhW is a low abundance protein. yhhW and yhaK paralogs, and homologs of human Pirin nuclear protein. [More information is available at EcoGene: EG12943]. YhhW was identified as a Pirin homolog and was shown to have quercetin 2,3-dioxygenase activity, releasing carbon monoxide. [More information is available at EcoCyc: G7756].
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Genomic context

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Sequence:
NC_000913.3 (3578950..3579645, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-gluconate kinase, thermostable Neighboring gene DNA-binding transcriptional repressor GntR Neighboring gene putative oxidoreductase YhhX Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Piecing together the structure-function puzzle: experiences in structure-based functional annotation of hypothetical proteins. Adams MA, et al. Proteomics, 2007 Aug. PMID 17639604
  2. Enrichment of low abundance proteins of Escherichia coli by hydroxyapatite chromatography. Fountoulakis M, et al. Electrophoresis, 1999 Aug. PMID 10493123
  3. Structural and biochemical analysis reveal pirins to possess quercetinase activity. Adams M, et al. J Biol Chem, 2005 Aug 5. PMID 15951572
  4. Large-scale identification of protein-protein interaction of Escherichia coli K-12. Arifuzzaman M, et al. Genome Res, 2006 May. PMID 16606699, Free PMC Article
  5. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables quercetin 2,3-dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables quercetin 2,3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
quercetin 2,3-dioxygenase
NP_417896.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3578950..3579645 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417896.1 quercetin 2,3-dioxygenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417896.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FV80, A0A377BVL2
    Conserved Domains (1) summary
    COG1741
    Location:1 → 231
    YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]
Nucleotide Protein
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