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ftsE cell division protein FtsE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947968, updated on 3-Dec-2024

Summary

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Official Symbol
ftsE
Official Full Name
cell division protein FtsE
Primary source
ECOCYC:EG10340
Locus tag
b3463
See related
ASAP:ABE-0011313
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3447
Summary
Divisome, non-essential. [More information is available at EcoGene: EG10340]. FtsE is the putative ATP-binding protein component of an ATP-binding cassette (ABC) transporter. [More information is available at EcoCyc: EG10340].
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Genomic context

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Sequence:
NC_000913.3 (3602079..3602747, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene branched chain amino acid/phenylalanine ABC transporter periplasmic binding protein Neighboring gene RNA polymerase sigma factor RpoH Neighboring gene cell division protein FtsX Neighboring gene signal recognition particle receptor Neighboring gene 16S rRNA m(2)G966 methyltransferase Neighboring gene DUF1145 domain-containing protein YhhL

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Localised mutagenesis of the fts YEX operon: conditionally lethal missense substitutions in the FtsE cell division protein of Escherichia coli are similar to those found in the cystic fibrosis transmembrane conductance regulator protein (CFTR) of human patients. Gibbs TW, et al. Mol Gen Genet, 1992 Jul. PMID 1379670
  2. Interaction between cell division proteins FtsE and FtsZ. Corbin BD, et al. J Bacteriol, 2007 Apr. PMID 17307852, Free PMC Article
  3. Genetic analysis of essential genes in the ftsE region of the Escherichia coli genetic map and identification of a new cell division gene, ftsS. Salmond GP, et al. Mol Gen Genet, 1984. PMID 6394955
  4. Division behavior and shape changes in isogenic ftsZ, ftsQ, ftsA, pbpB, and ftsE cell division mutants of Escherichia coli during temperature shift experiments. Taschner PE, et al. J Bacteriol, 1988 Apr. PMID 3280547, Free PMC Article
  5. FtsEX acts on FtsA to regulate divisome assembly and activity. Du S, et al. Proc Natl Acad Sci U S A, 2016 Aug 23. PMID 27503875, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Roles of ATP Hydrolysis by FtsEX and Interaction with FtsA in Regulation of Septal Peptidoglycan Synthesis and Hydrolysis.
    Title: Roles of ATP Hydrolysis by FtsEX and Interaction with FtsA in Regulation of Septal Peptidoglycan Synthesis and Hydrolysis.
  2. FtsEX first interacts with FtsZ to localize to the Z ring and then interacts with FtsA to promote divisome assembly and regulate septal peptidoglycan synthesis.
    Title: How FtsEX localizes to the Z ring and interacts with FtsA to regulate cell division.
  3. FtsEX acts on FtsA to regulate both divisome assembly and activity.
    Title: FtsEX acts on FtsA to regulate divisome assembly and activity.
  4. FtsE uses ATP to facilitate constriction rather than assembly of the septal ring.
    Title: ATP-binding site lesions in FtsE impair cell division.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in FtsZ-dependent cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in division septum assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in peptidoglycan turnover NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of ATPase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell division site NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in division septum IDA
Inferred from Direct Assay
more info
 PubMed 
part_of divisome complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extrinsic component of membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of plasma membrane protein complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
cell division protein FtsE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3602079..3602747 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417920.1 cell division protein FtsE [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417920.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AMZ6, A0A8S7E990
    Conserved Domains (1) summary
    PRK10908
    Location:1 → 222
    PRK10908; cell division ATP-binding protein FtsE
Nucleotide Protein
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