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tusA sulfur transfer protein TusA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947974, updated on 3-Dec-2024

Summary

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Official Symbol
tusA
Official Full Name
sulfur transfer protein TusA
Primary source
ECOCYC:EG12216
Locus tag
b3470
See related
ASAP:ABE-0011336
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3454; sirA; yhhP
Summary
SirA(TusA) interacts with and activates IscS, accepting sulfur from IscS to form C19 persulfide; transfers C19 persulfide to C78 of YheN(TusD). [More information is available at EcoGene: EG12216]. TusA functions as a sulfur mediator during synthesis of 2-thiouridine of the modified wobble base mnm5s2U in tRNA. [More information is available at EcoCyc: EG12216].
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Genomic context

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Sequence:
NC_000913.3 (3608751..3608996, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF07947 family protein YhhN Neighboring gene Zn(2(+))/Cd(2(+))/Pb(2(+)) exporting P-type ATPase Neighboring gene queuosine precursor transporter Neighboring gene periplasmic bacteriophage sensitivity protein DcrB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The sulfur carrier protein TusA has a pleiotropic role in Escherichia coli that also affects molybdenum cofactor biosynthesis. Dahl JU, et al. J Biol Chem, 2013 Feb 22. PMID 23281480, Free PMC Article
  2. The yhhP gene encoding a small ubiquitous protein is fundamental for normal cell growth of Escherichia coli. Yamashino T, et al. J Bacteriol, 1998 Apr. PMID 9555915, Free PMC Article
  3. High precision NMR structure of YhhP, a novel Escherichia coli protein implicated in cell division. Katoh E, et al. J Mol Biol, 2000 Nov 24. PMID 11080457
  4. TusA (YhhP) and IscS are required for molybdenum cofactor-dependent base-analog detoxification. Kozmin SG, et al. Microbiologyopen, 2013 Oct. PMID 23894086, Free PMC Article
  5. Deletion of the yhhP gene results in filamentous cell morphology in Escherichia coli. Ishii Y, et al. Biosci Biotechnol Biochem, 2000 Apr. PMID 10830496

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TusA (YhhP) and IscS are required for molybdenum cofactor-dependent base-analog detoxification.
    Title: TusA (YhhP) and IscS are required for molybdenum cofactor-dependent base-analog detoxification.
  2. sulfur carrier protein TusA has a pleiotropic role in Escherichia coli that also affects molybdenum cofactor biosynthesis
    Title: The sulfur carrier protein TusA has a pleiotropic role in Escherichia coli that also affects molybdenum cofactor biosynthesis.
  3. study determined the crystal structures of IscS-IscU and IscS-TusA complexes providing the first insight into their different modes of binding and the mechanism of sulfur transfer
    Title: Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sulfur carrier activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfur carrier activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-cysteine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA modification IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble position uridine thiolation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA wobble position uridine thiolation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA wobble position uridine thiolation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of IscS-TusA complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sulfur transfer protein TusA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3608751..3608996 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417927.1 sulfur transfer protein TusA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417927.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    PRK00299
    Location:1 → 80
    PRK00299; sulfurtransferase TusA
Nucleotide Protein
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