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prlC oligopeptidase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948016, updated on 3-Dec-2024

Summary

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Official Symbol
prlC
Official Full Name
oligopeptidase A
Primary source
ECOCYC:EG11441
Locus tag
b3498
See related
ASAP:ABE-0011421
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3483; opdA
Summary
Oligopeptidase A is a cytoplasmic protease with broad specificity. [More information is available at EcoCyc: EG11441].
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Genomic context

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Sequence:
NC_000913.3 (3643140..3645182, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene dipeptide/tripeptide:H(+) symporter DtpB Neighboring gene 16S rRNA m(2)G1516 methyltransferase Neighboring gene 23S rRNA m(6)A2030 methyltransferase Neighboring gene glutathione reductase (NADPH)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinetic characterization of the Escherichia coli oligopeptidase A (OpdA) and the role of the Tyr(607) residue. Lorenzon RZ, et al. Arch Biochem Biophys, 2010 Aug 15. PMID 20513640
  2. Escherichia coli prlC encodes an endopeptidase and is homologous to the Salmonella typhimurium opdA gene. Conlin CA, et al. J Bacteriol, 1992 Sep. PMID 1325967, Free PMC Article
  3. Purification and characterization of proteinase In, a trypsin-like proteinase, in Escherichia coli. Kato M, et al. Eur J Biochem, 1992 Dec 15. PMID 1336454
  4. PrlC, a suppressor of signal sequence mutations in Escherichia coli, can direct the insertion of the signal sequence into the membrane. Trun NJ, et al. J Mol Biol, 1989 Feb 20. PMID 2538634
  5. Characterization and in vivo cloning of prlC, a suppressor of signal sequence mutations in Escherichia coli K12. Trun NJ, et al. Genetics, 1987 Aug. PMID 2957272, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinetic parameters showed the importance of Tyr(607) in OpdA activity as its substitution promoted a decrease in the k(cat)/K(m) value of about 100-fold with Y607F mutant and 1000-fold with Y607A. Both mutations, however, did not affect protein folding.
    Title: Kinetic characterization of the Escherichia coli oligopeptidase A (OpdA) and the role of the Tyr(607) residue.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Escherichia coli prlC gene encodes a trypsin-like proteinase regulating the cell cycle.
  3. OpdA efficiently cleaves the peptides generated by the activity of the three primary ATP-dependent proteases from E. coli-Lon, HslUV, and ClpAP
    Title: Support for a potential role of E. coli oligopeptidase A in protein degradation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication TAS
Traceable Author Statement
more info
 PubMed 
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal peptide processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
oligopeptidase A
NP_417955.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3643140..3645182 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417955.1 oligopeptidase A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417955.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N2Z836
    Conserved Domains (1) summary
    PRK10911
    Location:1 → 680
    PRK10911; oligopeptidase A; Provisional
Nucleotide Protein
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