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gadW DNA-binding transcriptional dual regulator GadW [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948029, updated on 17-Dec-2024

Summary

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Official Symbol
gadW
Official Full Name
DNA-binding transcriptional dual regulator GadW
Primary source
ECOCYC:EG12242
Locus tag
b3515
See related
ASAP:ABE-0011482
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3499; yhiW
Summary
AraC family. [More information is available at EcoGene: EG12242]. GadW is a protein that belongs to the AraC/XylS family. [More information is available at EcoCyc: EG12242].
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Genomic context

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Sequence:
NC_000913.3 (3663890..3664618, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump membrane fusion protein MdtE Neighboring gene multidrug efflux pump RND permease MdtF Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator GadX

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GadY, a small-RNA regulator of acid response genes in Escherichia coli. Opdyke JA, et al. J Bacteriol, 2004 Oct. PMID 15466020, Free PMC Article
  2. GadX/GadW-dependent regulation of the Escherichia coli acid fitness island: transcriptional control at the gadY-gadW divergent promoters and identification of four novel 42 bp GadX/GadW-specific binding sites. Tramonti A, et al. Mol Microbiol, 2008 Nov. PMID 18808381
  3. pH-Dependent modulation of cyclic AMP levels and GadW-dependent repression of RpoS affect synthesis of the GadX regulator and Escherichia coli acid resistance. Ma Z, et al. J Bacteriol, 2003 Dec. PMID 14617649, Free PMC Article
  4. Collaborative regulation of Escherichia coli glutamate-dependent acid resistance by two AraC-like regulators, GadX and GadW (YhiW). Ma Z, et al. J Bacteriol, 2002 Dec. PMID 12446650, Free PMC Article
  5. Transcriptional expression of Escherichia coli glutamate-dependent acid resistance genes gadA and gadBC in an hns rpoS mutant. Waterman SR, et al. J Bacteriol, 2003 Aug. PMID 12867478, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results show how GadEWX simultaneously coordinate many cellular processes to produce the overall response of E. coli to acid stress.
    Title: Decoding genome-wide GadEWX-transcriptional regulatory networks reveals multifaceted cellular responses to acid stress in Escherichia coli.
  2. GadX/GadW-dependent activation of the acid fitness island is controlled at the gadX-gadW intergenic region, in which the gadY gene is located and transcribed divergently from gadW.
    Title: GadX/GadW-dependent regulation of the Escherichia coli acid fitness island: transcriptional control at the gadY-gadW divergent promoters and identification of four novel 42 bp GadX/GadW-specific binding sites.
  3. The effects of sodium on the acid resistance system of GadA/BC expression appears to be through the modulation of GadX and GadW activity, which in turn controls GadE expression.
    Title: Sodium regulates Escherichia coli acid resistance, and influences GadX- and GadW-dependent activation of gadE.
  4. The AraC-family regulators GadX and GadW, previously found to activate gadA/BC in vitro, are now shown in vivo to directly activate gadE expression, which, in turn, activates the gadA/BC genes.
    Title: The Escherichia coli AraC-family regulators GadX and GadW activate gadE, the central activator of glutamate-dependent acid resistance.
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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator GadW

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3663890..3664618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417972.1 DNA-binding transcriptional dual regulator GadW [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417972.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7E6W8
    Conserved Domains (1) summary
    cl30840
    Location:1 → 235
    PRK09940; transcriptional regulator YdeO; Provisional
Nucleotide Protein
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