mdtE multidrug efflux pump membrane fusion protein MdtE [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: mdtE
Official Full Name: multidrug efflux pump membrane fusion protein MdtE
Primary source: ECOCYC:EG12240
Locus tag: b3513
See related: ASAP:ABE-0011478
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3497; yhiU
Summary: EvgAS regulon. [More information is available at EcoGene: EG12240]. MdtE has similarity to AcrA, but production of MdtE does not suppress an acrA mutant defect in efflux function with AcrB . [More information is available at EcoCyc: EG12240].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12.
Title: Extreme Acid Modulates Fitness Trade-Offs of Multidrug Efflux Pumps MdtEF-TolC and AcrAB-TolC in Escherichia coli K-12.
GadX increases multidrug resistance in E. coli through activation of the MdtEF efflux pump.
Title: The AraC-family regulator GadX enhances multidrug resistance in Escherichia coli by activating expression of mdtEF multidrug efflux genes.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bile acid and bile salt transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to antibiotic	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to antibiotic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to antibiotic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within xenobiotic transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info