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gabT 4-aminobutyrate aminotransferase GabT [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948067, updated on 3-Dec-2024

Summary

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Official Symbol
gabT
Official Full Name
4-aminobutyrate aminotransferase GabT
Primary source
ECOCYC:EG10361
Locus tag
b2662
See related
ASAP:ABE-0008760
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2656
Summary
4-aminobutyrate aminotransferase is the initial enzyme of the 4-aminobutyrate (GABA) degradation pathway . [More information is available at EcoCyc: EG10361].
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Genomic context

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Sequence:
NC_000913.3 (2792735..2794015)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene succinate-semialdehyde dehydrogenase (NADP(+)) GabD Neighboring gene 4-aminobutanoate:H(+) symporter Neighboring gene DNA-binding transcriptional repressor GlaR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stereospecific production of the herbicide phosphinothricin (glufosinate) by transamination: isolation and characterization of a phosphinothricin-specific transaminase from Escherichia coli. Schulz A, et al. Appl Environ Microbiol, 1990 Jan. PMID 2178550, Free PMC Article
  2. Stereospecific production of the herbicide phosphinothricin (glufosinate) by transamination: cloning, characterization, and overexpression of the gene encoding a phosphinothricin-specific transaminase from Escherichia coli. Bartsch K, et al. Appl Environ Microbiol, 1990 Jan. PMID 2178553, Free PMC Article
  3. Kinetic and crystallographic analysis of active site mutants of Escherichia coli gamma-aminobutyrate aminotransferase. Liu W, et al. Biochemistry, 2005 Mar 1. PMID 15723541
  4. Crystal structures of unbound and aminooxyacetate-bound Escherichia coli gamma-aminobutyrate aminotransferase. Liu W, et al. Biochemistry, 2004 Aug 31. PMID 15323550
  5. Aminotransferases: demonstration of homology and division into evolutionary subgroups. Mehta PK, et al. Eur J Biochem, 1993 Jun 1. PMID 8513804

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Stereospecific production of the herbicide phosphinothricin (glufosinate) by transamination: isolation and characterization of a phosphinothricin-specific transaminase from Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4-aminobutyrate:2-oxoglutarate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-aminobutyrate:2-oxoglutarate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables 5-aminovalerate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5-aminovalerate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within arginine biosynthetic process via ornithine IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in gamma-aminobutyric acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamma-aminobutyric acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
4-aminobutyrate aminotransferase GabT
NP_417148.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2792735..2794015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417148.1 4-aminobutyrate aminotransferase GabT [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417148.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1X3JDC1
    Conserved Domains (1) summary
    PRK08088
    Location:1 → 425
    PRK08088; 4-aminobutyrate--2-oxoglutarate transaminase
Nucleotide Protein
Heading Accession and Version

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