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gpsA glycerol-3-phosphate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948125, updated on 3-Dec-2024

Summary

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Official Symbol
gpsA
Official Full Name
glycerol-3-phosphate dehydrogenase
Primary source
ECOCYC:EG20091
Locus tag
b3608
See related
ASAP:ABE-0011795
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3598
Summary
The enzyme catalyzes the NAD(P)H-dependent reduction of the glycolytic intermediate dihydroxyacetone-phosphate to produce glycerol-3-phosphate, a precursor for the biosynthesis of phospholipids . [More information is available at EcoCyc: EG20091].
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Genomic context

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Sequence:
NC_000913.3 (3782642..3783661, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA (cytidine/uridine-2'-O)-ribose methyltransferase Neighboring gene serine acetyltransferase Neighboring gene protein export chaperone SecB Neighboring gene reduced glutaredoxin 3 Neighboring gene putative sulfurtransferase YibN

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biosynthesis in Escherichia coli of sn-glycerol 3-phosphate, a precursor of phospholipid. Kinetic characterization of wild type and feedback-resistant forms of the biosynthetic sn-glycerol-3-phosphate dehydrogenase. Edgar JR, et al. J Biol Chem, 1978 Sep 25. PMID 28326
  2. Biosynthesis in Escherichia coli of sn-glycerol 3-phosphate, a precursor of phospholipid. Palmitoyl-CoA inhibition of the biosynthetic sn-glycerol-3-phosphate dehydrogenase. Edgar JR, et al. J Biol Chem, 1979 Feb 25. PMID 368067
  3. Expression of gpsA encoding biosynthetic sn-glycerol 3-phosphate dehydrogenase suppresses both the LB- phenotype of a secB null mutant and the cold-sensitive phenotype of a secG null mutant. Shimizu H, et al. Mol Microbiol, 1997 Dec. PMID 9426138
  4. Purification and regulatory properties of the biosynthetic L-glycerol 3-phosphate dehydrogenase from Escherichia coli. Kito M, et al. J Biol Chem, 1969 Jun 25. PMID 4389388
  5. Dependence of peptidoglycan metabolism on phospholipid synthesis during growth of Escherichia coli. Rodionov DG, et al. Microbiology (Reading), 1996 Oct. PMID 8885403

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. determined the structures of GlpD complexed with substrate analogues phosphoenolpyruvate, glyceric acid 2-phosphate, glyceraldehyde-3-phosphate, and product, dihydroxyacetone phosphate
    Title: Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerophospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycerophospholipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerophospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glycerol-3-phosphate dehydrogenase
NP_418065.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3782642..3783661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418065.1 glycerol-3-phosphate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418065.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376JT63, A0A5B9ANX3
    Conserved Domains (1) summary
    PRK00094
    Location:6 → 330
    gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
Nucleotide Protein
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