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ibpA small heat shock protein IbpA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948200, updated on 3-Dec-2024

Summary

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Official Symbol
ibpA
Official Full Name
small heat shock protein IbpA
Primary source
ECOCYC:EG11534
Locus tag
b3687
See related
ASAP:ABE-0012058
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3679; hslT; htpN
Summary
RpoH regulon. [More information is available at EcoGene: EG11534]. IbpA is a small heat shock protein that binds to aggregated proteins and inclusion bodies formed during heterologous protein expression . [More information is available at EcoCyc: EG11534].
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Genomic context

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Sequence:
NC_000913.3 (3867009..3867422, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative DNA-binding transcriptional regulator YidP Neighboring gene putative transport protein YidE Neighboring gene small heat shock protein IbpB Neighboring gene DUF1375 domain-containing putative lipoprotein YidQ Neighboring gene DUF3748 domain-containing galacturonate catabolism protein YidR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mRNA binding-mediated self-regulatory function of small heat shock protein IbpA in γ-proteobacteria is conferred by a conserved arginine. Cheng Y, et al. J Biol Chem, 2023 Sep. PMID 37517700, Free PMC Article
  2. Escherichia coli small heat shock protein IbpA is an aggregation-sensor that self-regulates its own expression at posttranscriptional levels. Miwa T, et al. Mol Microbiol, 2021 Jan. PMID 32959419
  3. Roles and applications of small heat shock proteins in the production of recombinant proteins in Escherichia coli. Han MJ, et al. Biotechnol Bioeng, 2004 Nov 20. PMID 15382106
  4. The Escherichia coli ibpA thermometer is comprised of stable and unstable structural elements. Waldminghaus T, et al. RNA Biol, 2009 Sep-Oct. PMID 19535917
  5. RNA thermometers are common in alpha- and gamma-proteobacteria. Waldminghaus T, et al. Biol Chem, 2005 Dec. PMID 16336122

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IbpAB small heat shock proteins are not host factors for bacteriophage varphiX174 replication.
    Title: IbpAB small heat shock proteins are not host factors for bacteriophage ϕX174 replication.
  2. Escherichia coli small heat shock protein IbpA plays a role in regulating the heat shock response by controlling the translation of sigma[32].
    Title: Escherichia coli small heat shock protein IbpA plays a role in regulating the heat shock response by controlling the translation of σ(32).
  3. The mRNA binding-mediated self-regulatory function of small heat shock protein IbpA in gamma-proteobacteria is conferred by a conserved arginine.
    Title: The mRNA binding-mediated self-regulatory function of small heat shock protein IbpA in γ-proteobacteria is conferred by a conserved arginine.
  4. Translation of ibpA is controlled by an RNA thermometer in its 5' untranslated region, forming a secondary structure that blocks entry of the ribosome at low temperatures.
    Title: Multiple layers of control govern expression of the Escherichia coli ibpAB heat-shock operon.
  5. The authors report that IbpA and IbpB, the sHSPs of Escherichia coli, are substrates for the AAA+ Lon protease.
    Title: The IbpA and IbpB small heat-shock proteins are substrates of the AAA+ Lon protease.
  6. The lack of IbpAB proteins in E. coli cells results in endogenous oxidative stress and overproduction of extracellular indole, which inhibits the growth of the biofilm at the air-liquid interface.
    Title: Escherichia coli heat-shock proteins IbpA and IbpB affect biofilm formation by influencing the level of extracellular indole.
  7. N-terminus verified by Edman degradation on complete protein
    Title: Two novel heat shock genes encoding proteins produced in response to heterologous protein expression in Escherichia coli.
  8. IbpA cooperates with IbpB in stabilization of thermally aggregated proteins in a disaggregation competent state
    Title: The small heat shock protein IbpA of Escherichia coli cooperates with IbpB in stabilization of thermally aggregated proteins in a disaggregation competent state.
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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small heat shock protein IbpA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3867009..3867422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418142.1 small heat shock protein IbpA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418142.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A192CFC5, A0AA36P8Y3, D3H312, Q1R4P9
    Conserved Domains (1) summary
    PRK10743
    Location:1 → 137
    PRK10743; heat shock chaperone IbpA
Nucleotide Protein
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