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yidC membrane protein insertase YidC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948214, updated on 17-Dec-2024

Summary

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Official Symbol
yidC
Official Full Name
membrane protein insertase YidC
Primary source
ECOCYC:EG11197
Locus tag
b3705
See related
ASAP:ABE-0012120
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3698
Summary
yidC is an essential gene. [More information is available at EcoGene: EG11197]. YidC mediates membrane insertion/assembly of inner membrane proteins . [More information is available at EcoCyc: EG11197].
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Genomic context

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Sequence:
NC_000913.3 (3885076..3886722)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal subunit protein L34 Neighboring gene RNase P protein component Neighboring gene membrane protein insertion efficiency factor Neighboring gene 5-carboxymethylaminomethyluridine-tRNA synthase GTPase subunit Neighboring gene tnaAB operon leader peptide

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. YidC is involved in the biogenesis of anaerobic respiratory complexes in the inner membrane of Escherichia coli. Price CE, et al. J Biol Chem, 2008 Oct 3. PMID 18635537
  2. YidC family members are involved in the membrane insertion, lateral integration, folding, and assembly of membrane proteins. Dalbey RE, et al. J Cell Biol, 2004 Sep 13. PMID 15364957, Free PMC Article
  3. Making membranes in bacteria. Stuart RA, et al. Nature, 2000 Aug 10. PMID 10949283
  4. Targeting, insertion, and localization of Escherichia coli YidC. Urbanus ML, et al. J Biol Chem, 2002 Apr 12. PMID 11821429
  5. Phylogenetic and structural analyses of the oxa1 family of protein translocases. Yen MR, et al. FEMS Microbiol Lett, 2001 Nov 13. PMID 11731127

See all (120) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Monitoring the binding and insertion of a single transmembrane protein by an insertase.
    Title: Monitoring the binding and insertion of a single transmembrane protein by an insertase.
  2. The Escherichia coli Outer Membrane beta-Barrel Assembly Machinery (BAM) Crosstalks with the Divisome.
    Title: The Escherichia coli Outer Membrane β-Barrel Assembly Machinery (BAM) Crosstalks with the Divisome.
  3. Membrane Insertion of the M13 Minor Coat Protein G3p Is Dependent on YidC and the SecAYEG Translocase.
    Title: Membrane Insertion of the M13 Minor Coat Protein G3p Is Dependent on YidC and the SecAYEG Translocase.
  4. Both PpiD and YidC contacted the lateral gate, the plug domain, and the periplasmic cavity of SecY.
    Title: Noncompetitive binding of PpiD and YidC to the SecYEG translocon expands the global view on the SecYEG interactome in Escherichia coli.
  5. In addition to providing virtual insights about how YidC inserts single-spanning membrane proteins, our study also demonstrates a valuable in vivo tracking method that can be applied to study more complicated substrates or other translocases.
    Title: Tracking the Stepwise Movement of a Membrane-inserting Protein In Vivo.
  6. YidC rapidly and efficiently binds to substrate proteins and leads to their integration into the liposome bilayer
    Title: YidC-mediated membrane insertion.
  7. The crystal structure of membrane transport protein YidC (YidC) and molecular dynamics simulation indicate that the intrinsic flexible C2 loop covered the positively charged cavity.
    Title: 2.8-Å crystal structure of Escherichia coli YidC revealing all core regions, including flexible C2 loop.
  8. We suggest that EH1 serves as a mechanical lever, facilitating a coordinated movement of YidC TMDs to trigger the release of nascent chains into the membrane.
    Title: Structural Dynamics of the YidC:Ribosome Complex during Membrane Protein Biogenesis.
  9. The YidC prevents LacY from misfolding by stabilizing the unfolded state from which LacY inserts structural segments stepwise into the membrane until folding is completed. During stepwise insertion, YidC and the membrane together stabilize the transient folds.
    Title: YidC assists the stepwise and stochastic folding of membrane proteins.
  10. Deletions in loop C1 affected the activity of YidC but did not influence ribosome binding or substrate insertion, whereas loop C2 was involved in ribosome binding. Combining the deletion with removal of the C terminus abolished YidC-mediated insertion.
    Title: Role of the Cytosolic Loop C2 and the C Terminus of YidC in Ribosome Binding and Insertion Activity.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables membrane insertase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables membrane insertase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables membrane insertase activity IEA
Inferred from Electronic Annotation
more info
  
enables membrane insertase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein insertion into membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein insertion into membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein insertion into membrane from inner side IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport by the Sec complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cell envelope Sec protein transport complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cell envelope Sec protein transport complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
membrane protein insertase YidC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3885076..3886722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418161.1 membrane protein insertase YidC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418161.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7ELE2
    Conserved Domains (1) summary
    PRK01318
    Location:1 → 548
    PRK01318; membrane protein insertase; Provisional
Nucleotide Protein
Heading Accession and Version

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