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mdtL efflux pump MdtL [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948219, updated on 3-Dec-2024

Summary

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Official Symbol
mdtL
Official Full Name
efflux pump MdtL
Primary source
ECOCYC:EG11720
Locus tag
b3710
See related
ASAP:ABE-0012139
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3703; yidY
Summary
Major Facilitator Superfamily (MFS). [More information is available at EcoGene: EG11720]. The YidY protein is, based on sequence similarity and hydropathy analysis, a member of the major facilitator superfamily (MFS) . [More information is available at EcoCyc: EG11720].
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Genomic context

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Sequence:
NC_000913.3 (3891615..3892790)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tryptophanase Neighboring gene tryptophan:H(+) symporter TnaB Neighboring gene DNA-binding transcriptional dual regulator YidZ Neighboring gene putative phosphopantetheinyl transferase Neighboring gene quinone reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Microbial genome analyses: comparative transport capabilities in eighteen prokaryotes. Paulsen IT, et al. J Mol Biol, 2000 Aug 4. PMID 10926494
  2. Proton-dependent multidrug efflux systems. Paulsen IT, et al. Microbiol Rev, 1996 Dec. PMID 8987357, Free PMC Article
  3. Analysis of a complete library of putative drug transporter genes in Escherichia coli. Nishino K, et al. J Bacteriol, 2001 Oct. PMID 11566977, Free PMC Article
  4. Microbial drug efflux proteins of the major facilitator superfamily. Saidijam M, et al. Curr Drug Targets, 2006 Jul. PMID 16842212
  5. The major facilitator superfamily. Saier MH Jr, et al. J Mol Microbiol Biotechnol, 1999 Nov. PMID 10943556

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
efflux pump MdtL

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3891615..3892790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418166.1 efflux pump MdtL [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418166.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6PMY2
    Conserved Domains (1) summary
    PRK10473
    Location:1 → 391
    PRK10473; MdtL family multidrug efflux MFS transporter
Nucleotide Protein
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