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ispD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948269, updated on 3-Dec-2024

Summary

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Official Symbol
ispD
Official Full Name
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Primary source
ECOCYC:G7423
Locus tag
b2747
See related
ASAP:ABE-0009017
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2742; ygbP
Summary
IspD is also called 4-diphosphocytidyl-2-C-methylerythritol synthase. [More information is available at EcoGene: EG13110]. 4-diphosphocytidyl-2C-methyl-D-erythritol synthase (IspD) catalyzes the third step in the methylerythritol phosphate pathway. [More information is available at EcoCyc: G7423].
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Genomic context

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Sequence:
NC_000913.3 (2871780..2872490, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein-L-isoaspartate O-methyltransferase Neighboring gene broad specificity 5'(3')-nucleotidase and polyphosphatase Neighboring gene tRNA pseudouridine(13) synthase Neighboring gene 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Neighboring gene cell division protein FtsB Neighboring gene DUF3561 domain-containing inner membrane protein YgbE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis. Richard SB, et al. Nat Struct Biol, 2001 Jul. PMID 11427897
  2. Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids. Richard SB, et al. Biochemistry, 2004 Sep 28. PMID 15379557
  3. Structure of a tetragonal crystal form of Escherichia coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase. Kemp LE, et al. Acta Crystallogr D Biol Crystallogr, 2003 Mar. PMID 12595740
  4. Crystallization and preliminary X-ray diffraction studies of recombinant Escherichia coli 4-diphosphocytidyl-2-C-methyl-D-erythritol synthetase. Kemp LE, et al. Acta Crystallogr D Biol Crystallogr, 2001 Aug. PMID 11468415
  5. The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate. Gabrielsen M, et al. FEBS J, 2006 Mar. PMID 16478479

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Cytidine 5'-triphosphate-dependent biosynthesis of isoprenoids: YgbP protein of Escherichia coli catalyzes the formation of 4-diphosphocytidyl-2-C-methylerythritol.
  2. quaternary structure and feedback regulation of enzyme activity
    Title: The crystal structure of a plant 2C-methyl-D-erythritol 4-phosphate cytidylyltransferase exhibits a distinct quaternary structure compared to bacterial homologues and a possible role in feedback regulation for cytidine monophosphate.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
NP_417227.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2871780..2872490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417227.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417227.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FVQ6, A0A376M5T8
    Conserved Domains (1) summary
    PRK00155
    Location:8 → 232
    ispD; D-ribitol-5-phosphate cytidylyltransferase
Nucleotide Protein
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