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ilvM acetolactate synthase II subunit IlvM [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948279, updated on 3-Dec-2024

Summary

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Official Symbol
ilvM
Official Full Name
acetolactate synthase II subunit IlvM
Primary source
ECOCYC:EG10501
Locus tag
b3769
See related
ASAP:ABE-0012313
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3761
Summary
The Salmonella IlvM N-terminal sequence (Schloss et al., 1985) and spacing to the RBS indicate the first ATG is used. [More information is available at EcoGene: EG10501]. Acetohydroxyacid synthase II (AHAS II) catalyzes the biosynthesis of -aceto--hydroxybutyrate and -acetolactate. [More information is available at EcoCyc: EG10501].
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Genomic context

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Sequence:
NC_000913.3 (3952201..3952464)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ilvXGMEDA operon leader peptide Neighboring gene uncharacterized protein IlvX Neighboring gene pseudo Neighboring gene branched-chain-amino-acid aminotransferase Neighboring gene dihydroxy-acid dehydratase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis and comparison of the internal promoter, pE, of the ilvGMEDA operons from Escherichia coli K-12 and Salmonella typhimurium. Lopes JM, et al. Nucleic Acids Res, 1986 Mar 25. PMID 3008097, Free PMC Article
  2. Binding and activation of thiamin diphosphate in acetohydroxyacid synthase. Bar-Ilan A, et al. Biochemistry, 2001 Oct 2. PMID 11570896
  3. Homology modeling of the structure of bacterial acetohydroxy acid synthase and examination of the active site by site-directed mutagenesis. Ibdah M, et al. Biochemistry, 1996 Dec 17. PMID 8973202
  4. Examination of the internal promoter, PE, in the ilvGMEDA operon of E. coli K-12. Wek RC, et al. Nucleic Acids Res, 1986 Mar 25. PMID 2421252, Free PMC Article
  5. Effects of deletion and insertion mutations in the ilvM gene of Escherichia coli. Lu MF, et al. J Bacteriol, 1987 Feb. PMID 3027038, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ilvM is able to activate the large subunits of all three acetolactate synthase I, II and III isozymes.
    Title: Interactions between large and small subunits of different acetohydroxyacid synthase isozymes of Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables acetolactate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetolactate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-valine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within amino acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of acetolactate synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
acetolactate synthase II subunit IlvM
NP_418217.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3952201..3952464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418217.1 acetolactate synthase II subunit IlvM [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418217.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S0FHH5
    Conserved Domains (1) summary
    PRK11152
    Location:1 → 76
    ilvM; acetolactate synthase 2 small subunit
Nucleotide Protein
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