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ppiC peptidyl-prolyl cis-trans isomerase C [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948285, updated on 3-Dec-2024

Summary

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Official Symbol
ppiC
Official Full Name
peptidyl-prolyl cis-trans isomerase C
Primary source
ECOCYC:EG12352
Locus tag
b3775
See related
ASAP:ABE-0012334
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3767; parvA
Summary
ppiC encodes a peptidyl-prolyl cis-trans isomerase, parvulin, which defines a new family of PPIases . [More information is available at EcoCyc: EG12352].
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Genomic context

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Sequence:
NC_000913.3 (3959532..3959813, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator IlvY Neighboring gene ketol-acid reductoisomerase (NADP(+)) Neighboring gene pseudo Neighboring gene ATP-dependent DNA helicase Rep

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Solution structure of Escherichia coli Par10: The prototypic member of the Parvulin family of peptidyl-prolyl cis/trans isomerases. Kühlewein A, et al. Protein Sci, 2004 Sep. PMID 15322281, Free PMC Article
  2. Confirmation of the existence of a third family among peptidyl-prolyl cis/trans isomerases. Amino acid sequence and recombinant production of parvulin. Rahfeld JU, et al. FEBS Lett, 1994 Sep 26. PMID 7925971
  3. Conserved sequence motifs in bacterial and bacteriophage chaperonins. Koonin EV, et al. Trends Biochem Sci, 1995 Jan. PMID 7878732
  4. The protein-free IANUS peptide array uncovers interaction sites between Escherichia coli parvulin 10 and alkyl hydroperoxide reductase. Malesević M, et al. Biochemistry, 2010 Oct 5. PMID 20806779
  5. Peptidyl prolyl cis/trans-isomerases: comparative reactivities of cyclophilins, FK506-binding proteins, and parvulins with fluorinated oligopeptide and protein substrates. Golbik R, et al. Biochemistry, 2005 Dec 13. PMID 16331962

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: A novel peptidyl-prolyl cis/trans isomerase from Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase C
NP_418223.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3959532..3959813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418223.1 peptidyl-prolyl cis-trans isomerase C [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418223.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9X1H9
    Conserved Domains (1) summary
    PRK15441
    Location:1 → 93
    PRK15441; peptidyl-prolyl cis-trans isomerase C; Provisional
Nucleotide Protein
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