U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pepQ Xaa-Pro dipeptidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948335, updated on 17-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
pepQ
Official Full Name
Xaa-Pro dipeptidase
Primary source
ECOCYC:EG10698
Locus tag
b3847
See related
ASAP:ABE-0012569
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3839
Summary
PepQ, a proline dipeptidase, hydrolyzes dipeptide substrates containing a proline residue at the carboxy-terminal end. [More information is available at EcoCyc: EG10698].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (4031161..4032492)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-ketoacyl-CoA thiolase Neighboring gene multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Delta(3)-cis- Delta(2)-trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase Neighboring gene IMPACT family member YigZ Neighboring gene K(+) transporter TrkH Neighboring gene protoporphyrinogen oxidase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Structural basis of substrate selectivity of E. coli prolidase. Weaver J, et al. PLoS One, 2014. PMID 25354344, Free PMC Article
  2. Catalytic properties of the PepQ prolidase from Escherichia coli. Park MS, et al. Arch Biochem Biophys, 2004 Sep 15. PMID 15313226
  3. GroEL actively stimulates folding of the endogenous substrate protein PepQ. Weaver J, et al. Nat Commun, 2017 Jun 30. PMID 28665408, Free PMC Article
  4. Soluble di- and aminopeptidases in Escherichia K-12. Dispensible enzymes. Hermsdorf CL, et al. Int J Pept Protein Res, 1979 Feb. PMID 372108
  5. Nucleotide sequence between the fadB gene and the rrnA operon from Escherichia coli. Nakahigashi K, et al. Nucleic Acids Res, 1990 Nov 11. PMID 2243799, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables aminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloexopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric triester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables proline dipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within peptide catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Xaa-Pro dipeptidase
NP_418289.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4031161..4032492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418289.1 Xaa-Pro dipeptidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418289.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1N4H2
    Conserved Domains (1) summary
    PRK13607
    Location:1 → 443
    PRK13607; proline dipeptidase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.