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mobA molybdenum cofactor guanylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948349, updated on 21-Jan-2025

Summary

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Official Symbol
mobA
Official Full Name
molybdenum cofactor guanylyltransferase
Primary source
ECOCYC:EG11829
Locus tag
b3857
See related
ASAP:ABE-0012593
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
chlB; ECK3849; mob; narB
Summary
In all enzymes that utilize molybdenum and tungsten cofactors (with the exception of nitrogenase) the metals are present in an oxidized state as molybdate or tungstate ions that are chelated by the cis-dithiolene moiety of a molybdenum cofactor. [More information is available at EcoCyc: EG11829].
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Genomic context

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Sequence:
NC_000913.3 (4041415..4041999, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 23S ribosomal RNA Neighboring gene 5S ribosomal RNA Neighboring gene molybdopterin-guanine dinucleotide biosynthesis adaptor protein Neighboring gene DUF1040 domain-containing protein YihD Neighboring gene stress response kinase A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The molybdenum cofactor of Escherichia coli nitrate reductase A (NarGHI). Effect of a mobAB mutation and interactions with [Fe-S] clusters. Rothery RA, et al. J Biol Chem, 1998 Mar 27. PMID 9516445
  2. Mapping of the gene chl-B controlling membran bound nitrate reductase and formic hydrogen-lyase activities in Escherichia coli K 12. Casse F. Biochem Biophys Res Commun, 1970 May 11. PMID 4912199
  3. Isolation of protein FA, a product of the mob locus required for molybdenum cofactor biosynthesis in Escherichia coli. Palmer T, et al. Eur J Biochem, 1994 Jun 1. PMID 8020507
  4. Involvement of a low-molecular-weight substance in in vitro activation of the molybdoenzyme respiratory nitrate reductase from a chlB mutant of Escherichia coli. Boxer DH, et al. J Bacteriol, 1987 Oct. PMID 3308848, Free PMC Article
  5. The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis. Lake MW, et al. J Biol Chem, 2000 Dec 22. PMID 10978347

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that bis-MGD formed by MobA is fully functional and restores the catalytic activity in apoTorA.
    Title: Identification of a bis-molybdopterin intermediate in molybdenum cofactor biosynthesis in Escherichia coli.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Isolation of protein FA, a product of the mob locus required for molybdenum cofactor biosynthesis in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables guanylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdenum cofactor guanylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables molybdenum cofactor guanylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in Mo-molybdopterin cofactor metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within bis(molybdopterin guanine dinucleotide)molybdenum biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
molybdenum cofactor guanylyltransferase
NP_418294.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4041415..4041999 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418294.1 molybdenum cofactor guanylyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418294.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN3M7R8
    Conserved Domains (1) summary
    PRK00317
    Location:4 → 194
    mobA; molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed
Nucleotide Protein
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