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rhaA L-rhamnose isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948400, updated on 3-Dec-2024

Summary

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Official Symbol
rhaA
Official Full Name
L-rhamnose isomerase
Primary source
ECOCYC:EG11867
Locus tag
b3903
See related
ASAP:ABE-0012736
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3896
Summary
RhaA also has L- lyxose isomerase activity and is needed for growth on L-lyxose (Badia, 1991). [More information is available at EcoGene: EG11867]. L-rhamnose isomerase catalyzes the first step in the utilization of the deoxyhexose sugar rhamnose. [More information is available at EcoCyc: EG11867].
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Genomic context

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Sequence:
NC_000913.3 (4094723..4095982, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-rhamnose mutarotase Neighboring gene rhamnulose-1-phosphate aldolase Neighboring gene rhamnulokinase Neighboring gene DNA-binding transcriptional activator RhaS Neighboring gene DNA-binding transcriptional activator RhaR Neighboring gene rhamnose/lyxose:H(+) symporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. THE METABOLISM OF L-RHAMNOSE IN ESCHERICHIA COLI. I. L-RHAMNOSE ISOMERASE. TAKAGI Y, et al. Biochim Biophys Acta, 1964 Oct 23. PMID 14243758
  2. The structure of rhamnose isomerase from Escherichia coli and its relation with xylose isomerase illustrates a change between inter and intra-subunit complementation during evolution. Korndörfer IP, et al. J Mol Biol, 2000 Jul 21. PMID 10891278
  3. Identification of the rhaA, rhaB and rhaD gene products from Escherichia coli K-12. Badía J, et al. FEMS Microbiol Lett, 1989 Dec. PMID 2558952
  4. The L-rhamnose genetic system in Escherichia coli K-12. Power J. Genetics, 1967 Mar. PMID 5341476, Free PMC Article
  5. DNA-dependent renaturation of an insoluble DNA binding protein. Identification of the RhaS binding site at rhaBAD. Egan SM, et al. J Mol Biol, 1994 Nov 11. PMID 7966303

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-rhamnose isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-rhamnose isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-rhamnose isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables rhamnose binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-lyxose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-lyxose metabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rhamnose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rhamnose catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within rhamnose catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rhamnose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
L-rhamnose isomerase
YP_026276.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4094723..4095982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026276.1 L-rhamnose isomerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026276.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1V2G545
    Conserved Domains (1) summary
    PRK01076
    Location:1 → 419
    PRK01076; L-rhamnose isomerase; Provisional
Nucleotide Protein
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