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zapB cell division factor ZapB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948420, updated on 3-Dec-2024

Summary

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Official Symbol
zapB
Official Full Name
cell division factor ZapB
Primary source
ECOCYC:EG11878
Locus tag
b3928
See related
ASAP:ABE-0012835
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3920; yiiU
Summary
ZapB forms filaments and binds FtsZ, presumably helping to form the initial Z-ring at the septum; septal localiztion of ZapB requires either FtsZ or ZipA; zapB mutants are elongated and have delayed cell division. [More information is available at EcoGene: EG11878]. The ZapB protein is a cell division factor that is required for proper Z ring formation. [More information is available at EcoCyc: EG11878].
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Genomic context

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Sequence:
NC_000913.3 (4118515..4118760)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycerol kinase Neighboring gene glycerol facilitator Neighboring gene ribonuclease E inhibitor protein A Neighboring gene 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interactions among the early Escherichia coli divisome proteins revealed by bimolecular fluorescence complementation. Pazos M, et al. Environ Microbiol, 2013 Dec. PMID 23957637
  2. A MatP-divisome interaction coordinates chromosome segregation with cell division in E. coli. Espéli O, et al. EMBO J, 2012 May 11. PMID 22580828, Free PMC Article
  3. FtsZ-ZapA-ZapB interactome of Escherichia coli. Galli E, et al. J Bacteriol, 2012 Jan. PMID 22056926, Free PMC Article
  4. Spatial resolution of two bacterial cell division proteins: ZapA recruits ZapB to the inner face of the Z-ring. Galli E, et al. Mol Microbiol, 2010 Jun. PMID 20487275
  5. The N-succinyl-l,l-diaminopimelic acid desuccinylase DapE acts through ZapB to promote septum formation in Escherichia coli. Du S, et al. Mol Microbiol, 2017 Jul. PMID 28470834, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the replication terminus attaches to the divisome in a single segment along the perimeter of the cell in a MatP, ZapA and ZapB proteins-dependent manner.
    Title: The role of MatP, ZapA and ZapB in chromosomal organization and dynamics in Escherichia coli.
  2. These results suggest that the main function of ZapA and ZapB in vivo may not be to promote the association of individual protofilaments but to align FtsZ clusters that consist of multiple FtsZ protofilaments.
    Title: In vivo organization of the FtsZ-ring by ZapA and ZapB revealed by quantitative super-resolution microscopy.
  3. The authors propose a molecular model in which ZapA increases lateral interactions between FtsZ proto-filaments and ZapB mediates further stabilization of this interaction by cross-linking ZapA molecules bound to adjacent FtsZ proto-filaments.
    Title: Spatial resolution of two bacterial cell division proteins: ZapA recruits ZapB to the inner face of the Z-ring.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in FtsZ-dependent cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in FtsZ-dependent cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell septum assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in division septum assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell division factor ZapB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4118515..4118760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418363.1 cell division factor ZapB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418363.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A192CEZ0, A0AA36L321
    Conserved Domains (1) summary
    PRK15422
    Location:3 → 81
    PRK15422; septal ring assembly protein ZapB; Provisional
Nucleotide Protein
Heading Accession and Version

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