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katG catalase/hydroperoxidase HPI [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948431, updated on 3-Dec-2024

Summary

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Official Symbol
katG
Official Full Name
catalase/hydroperoxidase HPI
Primary source
ECOCYC:EG10511
Locus tag
b3942
See related
ASAP:ABE-0012901
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3934
Summary
With AhpCF, KatG protects aerobic, phosphate-starved cells from oxidative damage. [More information is available at EcoGene: EG10511]. The KatG enzyme is a bifunctional hydroperoxidase I, having both catalase and peroxidase activity. [More information is available at EcoCyc: EG10511].
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Genomic context

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Sequence:
NC_000913.3 (4133835..4136015)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused aspartate kinase/homoserine dehydrogenase 2 Neighboring gene 5,10-methylenetetrahydrofolate reductase Neighboring gene cystine exporter Neighboring gene DUF1287 domain-containing protein YijF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Catalases HPI and HPII in Escherichia coli are induced independently. Loewen PC, et al. Arch Biochem Biophys, 1985 Nov 15. PMID 3904630
  2. The role of distal tryptophan in the bifunctional activity of catalase-peroxidases. Regelsberger G, et al. Biochem Soc Trans, 2001 May. PMID 11356135
  3. Modulation of the activities of catalase-peroxidase HPI of Escherichia coli by site-directed mutagenesis. Hillar A, et al. Biochemistry, 2000 May 16. PMID 10801338
  4. Intracellular location of catalase-peroxidase hydroperoxidase I of Escherichia coli. Hillar A, et al. FEMS Microbiol Lett, 1999 Jan 15. PMID 10068295
  5. Homeostatic regulation of intracellular hydrogen peroxide concentration in aerobically growing Escherichia coli. González-Flecha B, et al. J Bacteriol, 1997 Jan. PMID 8990289, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sixteen mutations were identified in KatG linked to isoniazid resistance in Mycobacterium tuberculosis.
    Title: Comparative study of enzymatic activities of new KatG mutants from low- and high-level isoniazid-resistant clinical isolates of Mycobacterium tuberculosis.
  2. Treatment of wild-type cells with proline significantly increased hydroperoxidase I (encoded by katG) expression and activity.
    Title: Proline metabolism increases katG expression and oxidative stress resistance in Escherichia coli.
  3. The quinone binding site modulates the electrochemical properties of heme b.
    Title: Q-site occupancy defines heme heterogeneity in Escherichia coli nitrate reductase A (NarGHI).
  4. peroxidase substrates have a central role in the unusual catalase mechanism of KatG
    Title: Stimulation of KatG catalase activity by peroxidatic electron donors.
  5. Data show that turnover and efficiency of peroxidase activity increases with decreasing pH until the protein unfolds.
    Title: The kinetic properties producing the perfunctory pH profiles of catalase-peroxidases.
  6. H2O2-inducible antioxidant defense system leading to an increase in HPI activity, is unaltered in Deltafur mutants
    Title: Reduced hydroperoxidase (HPI and HPII) activity in the Deltafur mutant contributes to increased sensitivity to UVA radiation in Escherichia coli.
  7. Hpx- (katG katE ahpCF) mutants of Escherichia coli have DNA damage from submicromolar intracellular hydrogen peroxide
    Title: Substantial DNA damage from submicromolar intracellular hydrogen peroxide detected in Hpx- mutants of Escherichia coli.
  8. X-ray crystallographic structure of the C-terminal domain of the catalase-peroxidase KatG from Escherichia coli
    Title: Structure of the C-terminal domain of the catalase-peroxidase KatG from Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables catalase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to hydrogen peroxide IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to oxidative stress IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
catalase/hydroperoxidase HPI
NP_418377.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4133835..4136015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418377.1 catalase/hydroperoxidase HPI [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418377.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9X119
    Conserved Domains (1) summary
    PRK15061
    Location:11 → 725
    PRK15061; catalase/peroxidase
Nucleotide Protein
Heading Accession and Version

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