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metA homoserine O-succinyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948513, updated on 17-Dec-2024

Summary

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Official Symbol
metA
Official Full Name
homoserine O-succinyltransferase
Primary source
ECOCYC:EG10581
Locus tag
b4013
See related
ASAP:ABE-0013121
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4005
Summary
MetA catalyzes the first step in methionine biosynthesis and is proteolytically unstable. [More information is available at EcoGene: EG10581].
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Genomic context

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Sequence:
NC_000913.3 (4214280..4215209)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene stress response protein Neighboring gene peptidyl-lysine N-acetyltransferase YjaB Neighboring gene malate synthase A Neighboring gene isocitrate lyase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence of the metA gene encoding homoserine trans-succinylase in Escherichia coli. Duclos B, et al. Nucleic Acids Res, 1989 Apr 11. PMID 2654885, Free PMC Article
  2. Probing the active site of homoserine trans-succinylase. Rosen R, et al. FEBS Lett, 2004 Nov 19. PMID 15556615
  3. In vivo aggregation of a single enzyme limits growth of Escherichia coli at elevated temperatures. Gur E, et al. Mol Microbiol, 2002 Dec. PMID 12453224
  4. Enzyme-catalyzed acylation of homoserine: mechanistic characterization of the Escherichia coli metA-encoded homoserine transsuccinylase. Born TL, et al. Biochemistry, 1999 Oct 26. PMID 10572016
  5. Physical mapping of the scattered methionine genes on the Escherichia coli chromosome. Old IG, et al. J Bacteriol, 1993 Jun. PMID 8501076, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MetA is a ""thermal fuse"" that inhibits growth and protects Escherichia coli at elevated temperatures.
    Title: MetA is a "thermal fuse" that inhibits growth and protects Escherichia coli at elevated temperatures.
  2. We found that potentiating mutations in metJ increase expression of metA, which encodes the first step of methionine biosynthesis. This increase in expression is required for the previously identified actualizing mutations in metA to generate cooperation.
    Title: Identification of the potentiating mutations and synergistic epistasis that enabled the evolution of inter-species cooperation.
  3. this is the first study to demonstrate manipulation of persister frequency under stressful conditions by stabilization of a single aggregation-prone protein, MetA.
    Title: Stabilization of homoserine-O-succinyltransferase (MetA) decreases the frequency of persisters in Escherichia coli under stressful conditions.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
homoserine O-succinyltransferase
NP_418437.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4214280..4215209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418437.1 homoserine O-succinyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418437.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAV3HY66
    Conserved Domains (1) summary
    PRK05368
    Location:1 → 302
    PRK05368; homoserine O-succinyltransferase; Provisional
Nucleotide Protein
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Gene LinkOut

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