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aceA isocitrate lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948517, updated on 17-Dec-2024

Summary

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Official Symbol
aceA
Official Full Name
isocitrate lyase
Primary source
ECOCYC:EG10022
Locus tag
b4015
See related
ASAP:ABE-0013128
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4007; icl
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Genomic context

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Sequence:
NC_000913.3 (4217109..4218413)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene homoserine O-succinyltransferase Neighboring gene malate synthase A Neighboring gene ncRNA Neighboring gene isocitrate dehydrogenase kinase/phosphatase Neighboring gene regulator of acetyl CoA synthetase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Site-directed mutagenesis of cysteine-195 in isocitrate lyase from Escherichia coli ML308. Robertson AG, et al. Biochem J, 1995 Jan 1. PMID 7826335, Free PMC Article
  2. Use of chemical modification in the crystallization of isocitrate lyase from Escherichia coli. Abeysinghe SI, et al. J Mol Biol, 1991 Jul 5. PMID 2067012
  3. The importance of four histidine residues in isocitrate lyase from Escherichia coli. Diehl P, et al. J Bacteriol, 1994 Feb. PMID 8300547, Free PMC Article
  4. Sub-optimal phenotypes of double-knockout mutants of Escherichia coli depend on the order of gene deletions. Gawand P, et al. Integr Biol (Camb), 2015 Aug. PMID 26079398, Free PMC Article
  5. The interaction of 3-phosphoglycerate and other substrate analogs with the glyoxylate- and succinate-binding sites of isocitrate lyase. Ko YH, et al. Arch Biochem Biophys, 1989 Oct. PMID 2673042

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Acid- and base-induced proteins during aerobic and anaerobic growth of Escherichia coli revealed by two-dimensional gel electrophoresis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cation binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables isocitrate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isocitrate lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isocitrate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glyoxylate cycle EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within glyoxylate cycle IC
Inferred by Curator
more info
 PubMed 
involved_in glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
isocitrate lyase
NP_418439.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4217109..4218413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418439.1 isocitrate lyase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418439.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A192CF72, A0A1X3HXQ7, A0A1X3J9F2, A0A829LCB4, A0AA36L2L3, A0AAN3M8L3, F4T6P7
    Conserved Domains (1) summary
    PRK15063
    Location:1 → 434
    PRK15063; isocitrate lyase; Provisional
Nucleotide Protein
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Gene LinkOut

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