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dusA tRNA-dihydrouridine synthase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948558, updated on 17-Dec-2024

Summary

Official Symbol
dusA
Official Full Name
tRNA-dihydrouridine synthase A
Primary source
ECOCYC:EG11932
Locus tag
b4049
See related
ASAP:ABE-0013258
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4041; yjbN
Summary
DusA is a tRNA-dihydrouridine synthase and accounts for about half of the 5,6-dihydrouridine modification observed in wild-type cellular tRNA, and DusB and DusC together account for the other half . [More information is available at EcoCyc: EG11932].
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Genomic context

Sequence:
NC_000913.3 (4261669..4262706)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein YjbL Neighboring gene DUF2713 domain-containing protein YjbM Neighboring gene phage shock protein G Neighboring gene ncRNA Neighboring gene putative quinone oxidoreductase 1

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA dihydrouridine synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables tRNA-dihydrouridine20 synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA-dihydrouridine20a synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in tRNA dihydrouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tRNA-dihydrouridine synthase A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4261669..4262706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418473.3 tRNA-dihydrouridine synthase A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418473.3

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9ANY6, A0A7I6H8M4, A7ZUS0
    Conserved Domains (1) summary
    PRK11815
    Location:16344
    PRK11815; tRNA dihydrouridine(20/20a) synthase DusA