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soxR DNA-binding transcriptional dual regulator SoxR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948566, updated on 3-Dec-2024

Summary

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Official Symbol
soxR
Official Full Name
DNA-binding transcriptional dual regulator SoxR
Primary source
ECOCYC:EG10957
Locus tag
b4063
See related
ASAP:ABE-0013316
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4055; marC
Summary
SoxR responds to superoxide and activates the SoxS global regulator in a regulatory cascade; reduced by RseC and RsxABCDGE. [More information is available at EcoGene: EG10957]. SoxR belongs to the MerR family of transcriptional regulators. [More information is available at EcoCyc: EG10957].
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Genomic context

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Sequence:
NC_000913.3 (4277469..4277933)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene c-di-GMP phosphodiesterase PdeC Neighboring gene DNA-binding transcriptional dual regulator SoxS Neighboring gene ncRNA Neighboring gene guanine/hypoxanthine transporter GhxP Neighboring gene putative transporter YjcE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional regulation via redox-sensitive iron-sulphur centres in an oxidative stress response. Demple B, et al. Biochem Soc Symp, 1999. PMID 10207625
  2. Binuclear [2Fe-2S] clusters in the Escherichia coli SoxR protein and role of the metal centers in transcription. Hidalgo E, et al. J Biol Chem, 1995 Sep 8. PMID 7673113
  3. An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein. Hidalgo E, et al. EMBO J, 1994 Jan 1. PMID 8306957, Free PMC Article
  4. Activation of SoxR-dependent transcription in vitro by noncatalytic or NifS-mediated assembly of [2Fe-2S] clusters into apo-SoxR. Hidalgo E, et al. J Biol Chem, 1996 Mar 29. PMID 8631739
  5. Glutathione-mediated destabilization in vitro of [2Fe-2S] centers in the SoxR regulatory protein. Ding H, et al. Proc Natl Acad Sci U S A, 1996 Sep 3. PMID 8790350, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The findings clearly support the idea that lysine is critical to the response to superoxide and further transcriptional activity of SoxR.
    Title: Rational Tuning of Superoxide Sensitivity in SoxR, the [2Fe-2S] Transcription Factor: Implications of Species-Specific Lysine Residues.
  2. Polyamines are involved in easing of oxidative stress through stimulation of synthesis of SoxR, EmrR and GshA together with RpoS.
    Title: Three members of polyamine modulon under oxidative stress conditions: two transcription factors (SoxR and EmrR) and a glutathione synthetic enzyme (GshA).
  3. Data indicate reaction of nitric oxide with transcription factor SoxR by pulse radiolysis.
    Title: Mechanistic studies on formation of the dinitrosyl iron complex of the [2Fe-2S] cluster of SoxR protein.
  4. This review focuses on the mechanisms by which SoxR proteins respond to oxidative stress.
    Title: Oxidative stress sensing by the iron-sulfur cluster in the transcription factor, SoxR.
  5. study compared responsiveness of SoxRs from Streptomyces coelicolor, Pseudomonas aeruginosa and E. coli towards redox-active compounds; ScSoxR is the most limited in the range of chemicals to which it responds and has highest reduction potential; both kinetic and redox potential factors determine range of effective chemicals
    Title: Comparative study of SoxR activation by redox-active compounds.
  6. Analysis of apo-SoxR binding determines that the effect of apo-SoxR on DNA triple-crossover molecules (TX) in the cohesive tract of a DNA-based mechanical device is similar to the effect of shortening the device by 2 base pairs.
    Title: A DNA-based nanomechanical device used to characterize the distortion of DNA by Apo-SoxR protein.
  7. The results indicate that activation of the soxRS regulon in E. coli cells exposed to superoxide-propagating compounds can be triggered by depletion of the NADPH stock rather than accumulation of superoxide itself.
    Title: The soxRS response of Escherichia coli can be induced in the absence of oxidative stress and oxygen by modulation of NADPH content.
  8. Conformational changes induced upon reduction of DNA-bound SoxR are not significantly different from those of DNA-free SoxR.
    Title: Protein conformational changes of the oxidative stress sensor, SoxR, upon redox changes of the [2Fe-2S] cluster probed with ultraviolet resonance Raman spectroscopy.
  9. mutant SoxR proteins contributed to the multiple-antibiotic resistance phenotypes of the clinical strains and were sufficient to confer multiple-antibiotic resistance in a fresh genetic background
    Title: Constitutive soxR mutations contribute to multiple-antibiotic resistance in clinical Escherichia coli isolates.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator SoxR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4277469..4277933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418487.1 DNA-binding transcriptional dual regulator SoxR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418487.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S0G411
    Conserved Domains (1) summary
    PRK15002
    Location:1 → 154
    PRK15002; redox-sensitive transcriptional activator SoxR
Nucleotide Protein
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