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phnH carbon-phosphorus lyase core complex subunit PhnH [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948619, updated on 17-Dec-2024

Summary

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Official Symbol
phnH
Official Full Name
carbon-phosphorus lyase core complex subunit PhnH
Primary source
ECOCYC:EG10717
Locus tag
b4100
See related
ASAP:ABE-0013430
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4093
Summary
Phosphonate utilization is cryptic in K-12. [More information is available at EcoGene: EG10717]. PhnH appears to be a component of a carbon-phosphorous lyase enzyme. phnHis part of an operon that is phosphate starvation-inducible and required for use of phosphonate and phosphite as phosphorous sources . [More information is available at EcoCyc: EG10717].
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Genomic context

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Sequence:
NC_000913.3 (4320663..4321247, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene carbon-phosphorus lyase subunit PhnK Neighboring gene carbon-phosphorus lyase core complex subunit PhnJ Neighboring gene carbon-phosphorus lyase core complex subunit PhnI Neighboring gene carbon-phosphorus lyase core complex subunit PhnG Neighboring gene putative transcriptional regulator PhnF Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure of PhnH: an essential component of carbon-phosphorus lyase in Escherichia coli. Adams MA, et al. J Bacteriol, 2008 Feb. PMID 17993513, Free PMC Article
  2. Accumulation of intermediates of the carbon-phosphorus lyase pathway for phosphonate degradation in phn mutants of Escherichia coli. Hove-Jensen B, et al. J Bacteriol, 2010 Jan. PMID 19854894, Free PMC Article
  3. Five phosphonate operon gene products as components of a multi-subunit complex of the carbon-phosphorus lyase pathway. Jochimsen B, et al. Proc Natl Acad Sci U S A, 2011 Jul 12. PMID 21705661, Free PMC Article
  4. Mapping and molecular cloning of the phn (psiD) locus for phosphonate utilization in Escherichia coli. Wanner BL, et al. J Bacteriol, 1990 Mar. PMID 2155195, Free PMC Article
  5. Phosphate-independent expression of the carbon-phosphorus lyase activity of Escherichia coli. Yakovleva GM, et al. Appl Microbiol Biotechnol, 1998 May. PMID 9650256

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within organic phosphonate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organic phosphonate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in organic phosphonate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organic phosphonate transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of carbon phosphorus lyase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of carbon phosphorus lyase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
carbon-phosphorus lyase core complex subunit PhnH
NP_418524.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4320663..4321247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418524.1 carbon-phosphorus lyase core complex subunit PhnH [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418524.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7L7ED51
    Conserved Domains (1) summary
    COG3625
    Location:1 → 193
    PhnH; Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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