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proP osmolyte:H(+) symporter ProP [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948626, updated on 3-Dec-2024

Summary

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Official Symbol
proP
Official Full Name
osmolyte:H(+) symporter ProP
Primary source
ECOCYC:EG11612
Locus tag
b4111
See related
ASAP:ABE-0013462
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4104
Summary
Mg(2+) stimulon-PhoPQ regulon, EvgAS-PhoPQ cascade enhanced-expression subset. [More information is available at EcoGene: EG11612]. ProP is an osmoprotectant/proton symporter capable of transporting proline and glycine betaine, and mediates the uptake of osmoprotectants to adapt to increases in osmotic pressure. [More information is available at EcoCyc: EG11612].
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Genomic context

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Sequence:
NC_000913.3 (4330502..4332004)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene zinc ribbon domain-containing protein YjdM Neighboring gene regulator of diguanylate cyclase RdcA Neighboring gene regulator of diguanylate cyclase RdcB Neighboring gene small regulatory membrane protein PmrR Neighboring gene sensor histidine kinase BasS Neighboring gene DNA-binding transcriptional dual regulator BasR Neighboring gene phosphoethanolamine transferase EptA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nanomolar levels of dimethylsulfoniopropionate, dimethylsulfonioacetate, and glycine betaine are sufficient to confer osmoprotection to Escherichia coli. Cosquer A, et al. Appl Environ Microbiol, 1999 Aug. PMID 10427011, Free PMC Article
  2. Identification and mapping of a second proline permease Salmonella typhimurium. Menzel R, et al. J Bacteriol, 1980 Mar. PMID 6245058, Free PMC Article
  3. Detection of alpha-helical coiled-coil dimer formation by spin-labeled synthetic peptides: a model parallel coiled-coil peptide and the antiparallel coiled coil formed by a replica of the ProP C-terminus. Hillar A, et al. Biochemistry, 2003 Dec 30. PMID 14690427
  4. Solution structure of the C-terminal antiparallel coiled-coil domain from Escherichia coli osmosensor ProP. Zoetewey DL, et al. J Mol Biol, 2003 Dec 12. PMID 14643666
  5. Osmosensing and osmoregulatory compatible solute accumulation by bacteria. Wood JM, et al. Comp Biochem Physiol A Mol Integr Physiol, 2001 Oct. PMID 11913457

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Improving L-threonine production in Escherichia coli by elimination of transporters ProP and ProVWX.
    Title: Improving L-threonine production in Escherichia coli by elimination of transporters ProP and ProVWX.
  2. ProP adopts a highly alpha-helical fold similar to that of LacY, and both transmembrane folds exhibit unusually high temperature-sensitive solvent accessibility
    Title: Structural characterization of the osmosensor ProP.
  3. Periplasmic loops of osmosensory transporter ProP in Escherichia coli are sensitive to osmolality
    Title: Periplasmic loops of osmosensory transporter ProP in Escherichia coli are sensitive to osmolality.
  4. ProP switches among "off", "on", and "osmolality-sensitive" states as the membrane potential increases.
    Title: Roles of K+, H+, H2O, and DeltaPsi in solute transport mediated by major facilitator superfamily members ProP and LacY.
  5. molecular model predicts the presence of a proton pathway within the N-terminal six-helix bundle of ProP
    Title: A structural model for the osmosensor, transporter, and osmoregulator ProP of Escherichia coli.
  6. These studies define position of ProP TM XII within the membrane, further support predicted structure of ProP, reveal the dimerization interface, and show that the structure of transmembrane segment XII influences the osmolality at which ProP activates.
    Title: Structure and function of transmembrane segment XII in osmosensor and osmoprotectant transporter ProP of Escherichia coli.
  7. Association of proP with cardiolipin (and not phosphatidylglycerol) may be required for polar ProP localization.
    Title: Cardiolipin promotes polar localization of osmosensory transporter ProP in Escherichia coli.
  8. study elucidates rules governing RpoS selectivity in presence of a class II activator, provide insight into transcriptional activation by Fis from this position & clarify, why the proP promoter is activated during a short time when Fis & RpoS are present
    Title: The -35 sequence location and the Fis-sigma factor interface determine sigmas selectivity of the proP (P2) promoter in Escherichia coli.
  9. ProP osmotic activation is tuned by both its C-terminal coiled-coil and osmotically induced changes in phospholipid composition
    Title: The osmotic activation of transporter ProP is tuned by both its C-terminal coiled-coil and osmotically induced changes in phospholipid composition.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables proline:proton symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular hyperosmotic response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular hyperosmotic salinity response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glycine betaine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in osmosensory signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proline import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proline import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proline import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
osmolyte:H(+) symporter ProP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4330502..4332004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418535.1 osmolyte:H(+) symporter ProP [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418535.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MF91, A0A6N8N9K8
    Conserved Domains (1) summary
    PRK10642
    Location:10 → 499
    PRK10642; proline/glycine betaine transporter ProP
Nucleotide Protein
Heading Accession and Version

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