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eptA phosphoethanolamine transferase EptA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948629, updated on 3-Dec-2024

Summary

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Official Symbol
eptA
Official Full Name
phosphoethanolamine transferase EptA
Primary source
ECOCYC:EG11613
Locus tag
b4114
See related
ASAP:ABE-0013469
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4107; yjdB
Summary
EptA co-localizes with ZipA. [More information is available at EcoGene: EG11613]. The YjdB protein can be found in the membrane in a complex with ZipA and an unidentified 24 kDa protein . [More information is available at EcoCyc: EG11613].
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Genomic context

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Sequence:
NC_000913.3 (4333947..4335590, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene osmolyte:H(+) symporter ProP Neighboring gene small regulatory membrane protein PmrR Neighboring gene sensor histidine kinase BasS Neighboring gene DNA-binding transcriptional dual regulator BasR Neighboring gene arginine:agmatine antiporter Neighboring gene DNA-binding transcriptional activator AdiY

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diacylglycerol Kinase A Is Essential for Polymyxin Resistance Provided by EptA, MCR-1, and Other Lipid A Phosphoethanolamine Transferases. Purcell AB, et al. J Bacteriol, 2022 Feb 15. PMID 34843376, Free PMC Article
  2. Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada. Tijet N, et al. PLoS One, 2017. PMID 28678874, Free PMC Article
  3. Abstracts of the 7th Conference of the International Endotoxin Society. Washington, DC, USA. 18-21 July 2002. . J Endotoxin Res, 2002. PMID 12184950
  4. Ovipleistophora gen. n., a new genus for Pleistophora mirandellae-like microsporidia. Pekkarinen M, et al. Dis Aquat Organ, 2002 Mar 11. PMID 12005235
  5. Novel members of the two-component signal transduction genes in Escherichia coli. Nagasawa S, et al. J Biochem, 1993 Sep. PMID 8282725

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Diacylglycerol Kinase A Is Essential for Polymyxin Resistance Provided by EptA, MCR-1, and Other Lipid A Phosphoethanolamine Transferases.
    Title: Diacylglycerol Kinase A Is Essential for Polymyxin Resistance Provided by EptA, MCR-1, and Other Lipid A Phosphoethanolamine Transferases.
  2. Data suggest that the plasmid-encoded phosphoethanolamine transferase MCR-1-harboring plasmid is playing an important role in spreading this mechanism of resistance to polymyxins.
    Title: Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada.
  3. YjdB, which co-localizes with the ZipA protein, is involved in cell division
    Title: Protein complexes of the Escherichia coli cell envelope.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables phosphotransferase activity, phosphate group as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphotransferase activity, phosphate group as acceptor TAS
Traceable Author Statement
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipopolysaccharide biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in lipopolysaccharide core region biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoethanolamine transferase EptA
NP_418538.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4333947..4335590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418538.2 phosphoethanolamine transferase EptA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418538.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1PLQ4
    Conserved Domains (1) summary
    PRK11598
    Location:2 → 546
    PRK11598; putative metal dependent hydrolase; Provisional
Nucleotide Protein
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