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basR DNA-binding transcriptional dual regulator BasR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948631, updated on 3-Dec-2024

Summary

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Official Symbol
basR
Official Full Name
DNA-binding transcriptional dual regulator BasR
Primary source
ECOCYC:EG11615
Locus tag
b4113
See related
ASAP:ABE-0013466
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4106; pmrA
Summary
BasS is the cognate sensor protein of the BasSR two-component system. [More information is available at EcoGene: EG11615]. The transcriptional regulatory protein BasR is part of the two-component BasS/BasR signal transduction system . [More information is available at EcoCyc: EG11615].
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Genomic context

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Sequence:
NC_000913.3 (4333282..4333950, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene osmolyte:H(+) symporter ProP Neighboring gene small regulatory membrane protein PmrR Neighboring gene sensor histidine kinase BasS Neighboring gene phosphoethanolamine transferase EptA Neighboring gene arginine:agmatine antiporter Neighboring gene DNA-binding transcriptional activator AdiY

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spontaneous pmrA mutants of Salmonella typhimurium LT2 define a new two-component regulatory system with a possible role in virulence. Roland KL, et al. J Bacteriol, 1993 Jul. PMID 8391535, Free PMC Article
  2. Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor. Guckes KR, et al. Proc Natl Acad Sci U S A, 2013 Oct 8. PMID 24062463, Free PMC Article
  3. Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates. Janssen AB, et al. mSphere, 2020 Mar 11. PMID 32161146, Free PMC Article
  4. Contribution of Novel Amino Acid Alterations in PmrA or PmrB to Colistin Resistance in mcr-Negative Escherichia coli Clinical Isolates, Including Major Multidrug-Resistant Lineages O25b:H4-ST131-H30Rx and Non-x. Sato T, et al. Antimicrob Agents Chemother, 2018 Sep. PMID 29914952, Free PMC Article
  5. The contribution of PmrAB to the virulence of a clinical isolate of Escherichia coli. Warner DM, et al. Virulence, 2013 Oct 1. PMID 23921442, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel type of colistin resistance genes selected from random sequence space.
    Title: A novel type of colistin resistance genes selected from random sequence space.
  2. Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates.
    Title: Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates.
  3. this study revealed that the colistin resistance mechanism of E. coli clinical isolates is due to novel amino acid substitutions and deletions in PmrAB that confer phosphoethanolamine transferase modification of lipid A.
    Title: Contribution of Novel Amino Acid Alterations in PmrA or PmrB to Colistin Resistance in mcr-Negative Escherichia coli Clinical Isolates, Including Major Multidrug-Resistant Lineages O25b:H4-ST131-H30Rx and Non-x.
  4. All components of the QseBC and PmrAB two-component systems (TCSs) are required for proper response to ferric iron.
    Title: Signaling by two-component system noncognate partners promotes intrinsic tolerance to polymyxin B in uropathogenic Escherichia coli.
  5. These findings suggest a role for the PmrAB two-component regulatory system in the virulence of Escherichia coli in a murine pyelonephritis model.
    Title: The contribution of PmrAB to the virulence of a clinical isolate of Escherichia coli.
  6. The PmrA response regulator contributes to qseB transcription in the absence of QseC and PmrA specifically binds the qseBC promoter, indicative of a direct regulation of qseBC gene transcription by PmrAB under physiological conditions.
    Title: Strong cross-system interactions drive the activation of the QseB response regulator in the absence of its cognate sensor.
  7. More than 20 novel targets are regulated by BasS-BasR two-component system.
    Title: Novel regulation targets of the metal-response BasS-BasR two-component system of Escherichia coli.
  8. PmrA-dependent inhibition of LpxT is required for phosphoethanolamine decoration of lipid A, which is shown here to be critical for Escherichia coli to resist the bactericidal activity of polymyxin.
    Title: Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay response regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphorelay response regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorelay signal transduction system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to iron(III) ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to iron(III) ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional dual regulator BasR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4333282..4333950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418537.1 DNA-binding transcriptional dual regulator BasR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418537.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AM05
    Conserved Domains (1) summary
    PRK10643
    Location:1 → 222
    PRK10643; two-component system response regulator PmrA
Nucleotide Protein
Heading Accession and Version

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