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basS sensor histidine kinase BasS [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948632, updated on 3-Dec-2024

Summary

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Official Symbol
basS
Official Full Name
sensor histidine kinase BasS
Primary source
ECOCYC:EG11614
Locus tag
b4112
See related
ASAP:ABE-0013464
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dgkR; ECK4105; pmrB
Summary
BasR is the cognate response regulator of the BasSR two-component system. [More information is available at EcoGene: EG11614]. BasS (bacterial adaptative response, sensor-kinase) belongs to the two component system BasS/BasR, is a sensor-histidine kinase and is known to be a transmembrane protein composed of three domains: external sensory domain (amino-terminal), cytoplasmic transmitter domain (carboxyl-terminal), and transmembrane hydrophobic central domain. [More information is available at EcoCyc: EG11614].
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Genomic context

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Sequence:
NC_000913.3 (4332181..4333272, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene regulator of diguanylate cyclase RdcA Neighboring gene regulator of diguanylate cyclase RdcB Neighboring gene osmolyte:H(+) symporter ProP Neighboring gene small regulatory membrane protein PmrR Neighboring gene DNA-binding transcriptional dual regulator BasR Neighboring gene phosphoethanolamine transferase EptA Neighboring gene arginine:agmatine antiporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli. Phan MD, et al. J Antimicrob Chemother, 2017 Oct 1. PMID 29091192
  2. PmrB Y358N, E123D amino acid substitutions are not associated with colistin resistance but with phylogeny in Escherichia coli. Butters A, et al. Microbiol Spectr, 2024 Oct 3. PMID 39162501, Free PMC Article
  3. A novel type of colistin resistance genes selected from random sequence space. Knopp M, et al. PLoS Genet, 2021 Jan. PMID 33411736, Free PMC Article
  4. Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates. Janssen AB, et al. mSphere, 2020 Mar 11. PMID 32161146, Free PMC Article
  5. Contribution of Novel Amino Acid Alterations in PmrA or PmrB to Colistin Resistance in mcr-Negative Escherichia coli Clinical Isolates, Including Major Multidrug-Resistant Lineages O25b:H4-ST131-H30Rx and Non-x. Sato T, et al. Antimicrob Agents Chemother, 2018 Sep. PMID 29914952, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PmrB Y358N, E123D amino acid substitutions are not associated with colistin resistance but with phylogeny in Escherichia coli.
    Title: PmrB Y358N, E123D amino acid substitutions are not associated with colistin resistance but with phylogeny in Escherichia coli.
  2. A novel type of colistin resistance genes selected from random sequence space.
    Title: A novel type of colistin resistance genes selected from random sequence space.
  3. Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates.
    Title: Nonclonal Emergence of Colistin Resistance Associated with Mutations in the BasRS Two-Component System in Escherichia coli Bloodstream Isolates.
  4. this study revealed that the colistin resistance mechanism of E. coli clinical isolates is due to novel amino acid substitutions and deletions in PmrAB that confer phosphoethanolamine transferase modification of lipid A.
    Title: Contribution of Novel Amino Acid Alterations in PmrA or PmrB to Colistin Resistance in mcr-Negative Escherichia coli Clinical Isolates, Including Major Multidrug-Resistant Lineages O25b:H4-ST131-H30Rx and Non-x.
  5. study identified the pmrB gene as the main chromosomal target for induction of colistin and polymyxin B resistance in E. coli
    Title: Modifications in the pmrB gene are the primary mechanism for the development of chromosomally encoded resistance to polymyxins in uropathogenic Escherichia coli.
  6. All components of the QseBC and PmrAB two-component systems (TCSs) are required for proper response to ferric iron.
    Title: Signaling by two-component system noncognate partners promotes intrinsic tolerance to polymyxin B in uropathogenic Escherichia coli.
  7. The presence of one sensor kinase, QseC, is required to regulate the interaction between the other sensor kinase, PmrB and the response regulators from both systems, QseB and PmrA, effectively creating a "four-component" system required for virulence.
    Title: The Histidine Residue of QseC Is Required for Canonical Signaling between QseB and PmrB in Uropathogenic Escherichia coli.
  8. These findings suggest a role for the PmrAB two-component regulatory system in the virulence of Escherichia coli in a murine pyelonephritis model.
    Title: The contribution of PmrAB to the virulence of a clinical isolate of Escherichia coli.
  9. More than 20 novel targets are regulated by BasS-BasR two-component system.
    Title: Novel regulation targets of the metal-response BasS-BasR two-component system of Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorelay sensor kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein histidine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphorelay signal transduction system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to iron(III) ion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to zinc ion IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
sensor histidine kinase BasS
NP_418536.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4332181..4333272 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418536.1 sensor histidine kinase BasS [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418536.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0B6XJQ3, A0A0N9R2N6, A0A0U2NVL1, A0A0U2Q2L2, A0A0U3A4Y2, A0A241QZ73, A0A5P9KEW2, G1E6D8, G1E6G6
    Conserved Domains (1) summary
    PRK10755
    Location:7 → 361
    PRK10755; two-component system sensor histidine kinase PmrB
Nucleotide Protein
Heading Accession and Version

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