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aspA aspartate ammonia-lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948658, updated on 3-Dec-2024

Summary

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Official Symbol
aspA
Official Full Name
aspartate ammonia-lyase
Primary source
ECOCYC:EG10095
Locus tag
b4139
See related
ASAP:ABE-0013551
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4133
Summary
Tetrameric enzyme. [More information is available at EcoGene: EG10095]. Aspartate-ammonia lyase (aspartase) carries out the reversible conversion of L-aspartate to fumarate and ammonia. [More information is available at EcoCyc: EG10095].
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Genomic context

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Sequence:
NC_000913.3 (4366891..4368327, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene thiol-disulfide exchange protein DsbD Neighboring gene copper binding protein CutA Neighboring gene C4-dicarboxylate transporter DcuA Neighboring gene ncRNA Neighboring gene protein FxsA Neighboring gene L-methionine/branched chain amino acid exporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Specific inhibition of aspartase by S-2,3-dicarboxyaziridine. Higashi Y, et al. Biochem Int, 1988 Mar. PMID 3289541
  2. Biospecific inactivation of aspartase by L-aspartic-beta-semialdehyde. Yumoto N, et al. Biochem Biophys Res Commun, 1982 Feb 11. PMID 7041905
  3. Studies on aspartase. VI. Trypsin-mediated activation releasing carboxy-terminal peptides. Yumoto N, et al. Biochim Biophys Acta, 1980 Dec 4. PMID 7011387
  4. Studies on aspartase VIII. Protease-mediated activation: comparative survey of protease specificity for activation and peptide cleavage. Yumoto N, et al. Physiol Chem Phys, 1982. PMID 6764538
  5. Chemical modification of essential histidine residues in aspartase with diethylpyrocarbonate. Ida N, et al. J Biochem, 1984 Nov. PMID 6396297

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Cloning and nucleotide sequence of the aspartase gene of Escherichia coli W.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables aspartate ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aspartate ammonia-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aspartate ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in aspartate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in aspartate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within aspartate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in aspartate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nitrogen utilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 

General protein information

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Preferred Names
aspartate ammonia-lyase
NP_418562.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4366891..4368327 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418562.4 aspartate ammonia-lyase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418562.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A418GD51
    Conserved Domains (1) summary
    PRK12273
    Location:1 → 473
    aspA; aspartate ammonia-lyase; Provisional
Nucleotide Protein
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