ampC beta-lactamase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: ampC
Official Full Name: beta-lactamase
Primary source: ECOCYC:EG10040
Locus tag: b4150
See related: ASAP:ABE-0013592
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ampA; ECK4146
Summary: False positive lipoprotein prediction. [More information is available at EcoGene: EG10040]. The ampC -lactamase gene encodes a serine cephalosporinase . [More information is available at EcoCyc: EG10040].
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Genomic context

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Sequence:: NC_000913.3 (4377811..4378944, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High-level ceftazidime/avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated beta-lactamase CMY-185 variant.
Title: High-level ceftazidime/avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated β-lactamase CMY-185 variant.
Clonal Relationship and Resistance Profiles Among ESBL-Producing Escherichia coli.
Title: Clonal Relationship and Resistance Profiles Among ESBL-Producing Escherichia coli.
Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019.
Title: Surveillance of OXA-244-producing Escherichia coli and epidemiologic investigation of cases, Denmark, January 2016 to August 2019.
Given the considerable spatial, temporal, and ecological factors, heterogeneity, which affects emergency response, persistence, and dissemination of genetic determinants that confer microorganisms their resistance to antibiotics, several authors claim that antibiotics' resistance must be perceived as an ecological problem. The aim of this study was to determine the prevalence of broad-spectrum bla genes, not only Extended
Title: ESBL and AmpC β-Lactamases in Clinical Strains of Escherichia coli from Serra da Estrela, Portugal.
These findings demonstrate that animal-based food products in HCMC represent a major reservoir of ESBL/pAmpC-producing E. coli.
Title: Dissemination of Extended-Spectrum β-Lactamase- and AmpC β-Lactamase-Producing Escherichia coli within the Food Distribution System of Ho Chi Minh City, Vietnam.
Recently, high-level AmpC production has also been seen in new species such as Escherichia coli via plasmid acquisition.
Title: Clinical management of infections caused by Enterobacteriaceae that express extended-spectrum β-lactamase and AmpC enzymes.
the majority of the strains of E. coli with AmpC-susceptibility pattern are pAmpC positive, although the association of extended-spectrum beta-lactamases (ESBL) and pAmpC is unusual.
Title: Diversity of bla genes and low incidence of CTX-M in plasmid-mediated AmpC-producing Escherichia coli clinical isolates.
A high prevalence of birds carries extended spectrumBL(ESBL)/AmpC-producing E. coli at Dutch broiler farms and a high prevalence of ESBL/AmpC-producing E. coli in farmers.
Title: Extended-spectrum-β-lactamase- and AmpC-β-lactamase-producing Escherichia coli in Dutch broilers and broiler farmers.
Extended-spectrum beta-lactamase-producing Escherichia coli from retail chicken meat and humans: comparison of strains, plasmids, resistance genes, and virulence factors.
Title: Extended-spectrum β-lactamase-producing Escherichia coli from retail chicken meat and humans: comparison of strains, plasmids, resistance genes, and virulence factors.
determined structure of ampC K67R mutant by X-ray crystallography in apo & transition state-analog complexed forms; results suggest arginine side chain is unable to play the same catalytic role as Lys67 in either the acylation or deacylation reactions
Title: Re-examining the role of Lys67 in class C beta-lactamase catalysis.

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General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables beta-lactamase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-lactamase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antibiotic catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in antibiotic catabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to antibiotic	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in outer membrane-bounded periplasmic space	IEA Inferred from Electronic Annotation more info
located_in periplasmic space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: beta-lactamase

NP_418574.1

EC 3.5.2.6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

4377811..4378944 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_418574.1 beta-lactamase [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_418574.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A0M4JL69, A0A0M4K1N3, A0A6M9WXB7

Conserved Domains (1) summary

PRK11289
Location:1 → 377

ampC; beta-lactamase/D-alanine carboxypeptidase; Provisional