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gdx guanidinium exporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948671, updated on 3-Dec-2024

Summary

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Official Symbol
gdx
Official Full Name
guanidinium exporter
Primary source
ECOCYC:EG11616
Locus tag
b4148
See related
ASAP:ABE-0013588
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4144; sugE
Summary
SugE belongs to the SMR efflux pump family, DMT superfamily. [More information is available at EcoGene: EG11616]. SugE is a member of the SMR family of proton-dependent drug efflux transporters . [More information is available at EcoCyc: EG11616].
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Genomic context

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Sequence:
NC_000913.3 (4376875..4377192)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene entericidin A lipoprotein, antidote to entericidin B Neighboring gene bacteriolytic entericidin B lipoprotein Neighboring gene outer membrane lipoprotein Blc Neighboring gene beta-lactamase Neighboring gene fumarate reductase membrane protein FrdD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spectroscopic analysis of the intrinsic chromophores within small multidrug resistance protein SugE. Bay DC, et al. Biochim Biophys Acta, 2011 Sep. PMID 21600871
  2. Guanidinium export is the primal function of SMR family transporters. Kermani AA, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507227, Free PMC Article
  3. A novel multicopy suppressor of a groEL mutation includes two nested open reading frames transcribed from different promoters. Greener T, et al. EMBO J, 1993 Mar. PMID 8096175, Free PMC Article
  4. Transcription attenuation: a highly conserved regulatory strategy used by bacteria. Merino E, et al. Trends Genet, 2005 May. PMID 15851059
  5. SMR proteins SugE and EmrE bind ligand with similar affinity and stoichiometry. Sikora CW, et al. Biochem Biophys Res Commun, 2005 Sep 16. PMID 16055085

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Spectroscopic analysis of the intrinsic chromophores within small multidrug resistance protein SugE
    Title: Spectroscopic analysis of the intrinsic chromophores within small multidrug resistance protein SugE.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanidinium exporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4376875..4377192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418572.4 guanidinium exporter [Escherichia coli str. K-12 substr. MG1655]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MPY8
    Conserved Domains (1) summary
    PRK11431
    Location:1 → 105
    PRK11431; quaternary ammonium compound efflux SMR transporter SugE
Nucleotide Protein
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