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aidB putative acyl-CoA dehydrogenase AidB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948710, updated on 17-Dec-2024

Summary

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Official Symbol
aidB
Official Full Name
putative acyl-CoA dehydrogenase AidB
Primary source
ECOCYC:EG11811
Locus tag
b4187
See related
ASAP:ABE-0013701
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4183
Summary
Induced by anaerobiosis and acetate. [More information is available at EcoGene: EG11811]. AidB is involved in the adaptive DNA-repair response of Escherichia coli to alkylating agents. [More information is available at EcoCyc: EG11811].
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Genomic context

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Sequence:
NC_000913.3 (4414275..4415900)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1190 domain-containing protein YjfM Neighboring gene putative acid--amine ligase YjfC Neighboring gene protease activator YjfN Neighboring gene DUF1471 domain-containing putative lipoprotein BsmA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Escherichia coli alkylation response protein AidB is a redox partner of flavodoxin and binds RNA and acyl carrier protein. Mulrooney SB, et al. Arch Biochem Biophys, 2011 Sep 15. PMID 21782785, Free PMC Article
  2. Induction of the alkylation-inducible aidB gene of Escherichia coli by anaerobiosis. Volkert MR, et al. J Bacteriol, 1989 Feb. PMID 2492508, Free PMC Article
  3. Hydrogen peroxide induces protection against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) effects in Escherichia coli. Asad LM, et al. Mutat Res, 1997 Mar 12. PMID 9088346
  4. Identification and expression of the SOS response, aidB-like, gene in the marine sponge Geodia cydonium: implication for the phylogenetic relationships of metazoan acyl-CoA dehydrogenases and acyl-CoA oxidases. Krasko A, et al. J Mol Evol, 1998 Sep. PMID 9732461
  5. Nucleotides from -16 to -12 determine specific promoter recognition by bacterial sigmaS-RNA polymerase. Lacour S, et al. J Biol Chem, 2003 Sep 26. PMID 12853450

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AidB exhibits several discrepancies from ACADs that suggest a novel catalytic mechanism distinct from that of the ACAD family enzymes.
    Title: Electrochemical characterization of Escherichia coli adaptive response protein AidB.
  2. AidB was found to bind to RNA, raising the prospect that the protein may have a role in protection of RNA from chemical alkylation.
    Title: The Escherichia coli alkylation response protein AidB is a redox partner of flavodoxin and binds RNA and acyl carrier protein.
  3. The N-terminal region, comprising the first 439 amino acids possesses dehydrogenase activity, while its C-terminal domain, corresponding to residues 440 to 541 displays DNA binding activity and can negatively regulate the expression of its own gene.
    Title: Specific DNA binding and regulation of its own expression by the AidB protein in Escherichia coli.
  4. a 1.7-A crystal structure of AidB, which bears superficial resemblance to the acyl-CoA dehydrogenase superfamily of flavoproteins
    Title: Structure and DNA binding of alkylation response protein AidB.
  5. AidB is shown to possess flavin adenine dinucleotide (FAD), low levels of isovaleryl-coenzyme A (CoA) dehydrogenase activity, and ability to bind DNA, and is predicted to catalyze the direct repair of alkylated DNA
    Title: The AidB component of the Escherichia coli adaptive response to alkylating agents is a flavin-containing, DNA-binding protein.
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Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-methylbutanoyl-CoA dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables acyl-CoA dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acyl-CoA dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative acyl-CoA dehydrogenase AidB
NP_418608.6

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4414275..4415900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418608.6 putative acyl-CoA dehydrogenase AidB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418608.6

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7E9R1, A0A9P2IBG5
    Conserved Domains (1) summary
    PRK11561
    Location:1 → 538
    PRK11561; isovaleryl CoA dehydrogenase; Provisional
Nucleotide Protein
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