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iadA isoaspartyl dipeptidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948853, updated on 3-Dec-2024

Summary

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Official Symbol
iadA
Official Full Name
isoaspartyl dipeptidase
Primary source
ECOCYC:G7925
Locus tag
b4328
See related
ASAP:ABE-0014195
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4319; yjiF
Summary
Isoaspartyl dipeptidase is a peptidase that breaks down linkages, the peptide bonds that can form spontaneously between the side chain of an aspartate residue and another amino acid . [More information is available at EcoCyc: G7925].
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Genomic context

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Sequence:
NC_000913.3 (4558354..4559526, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene iraD leader peptide Neighboring gene anti-adaptor protein IraD Neighboring gene DNA-binding transcriptional dual regulator HypT Neighboring gene Gate family protein YjiG Neighboring gene uncharacterized protein YjiH Neighboring gene RNA 2'-phosphotransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli. Martí-Arbona R, et al. Biochemistry, 2005 May 17. PMID 15882050
  2. X-ray structure of isoaspartyl dipeptidase from E.coli: a dinuclear zinc peptidase evolved from amidohydrolases. Jozic D, et al. J Mol Biol, 2003 Sep 5. PMID 12946361
  3. High-resolution X-ray structure of isoaspartyl dipeptidase from Escherichia coli. Thoden JB, et al. Biochemistry, 2003 May 6. PMID 12718528
  4. Purification and properties of a beta-aspartyl peptidase from Escherichia coli. Haley EE. J Biol Chem, 1968 Nov 10. PMID 4880759
  5. Purification and characterization of an isoaspartyl dipeptidase from Escherichia coli. Gary JD, et al. J Biol Chem, 1995 Feb 24. PMID 7876157

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Purification and characterization of an isoaspartyl dipeptidase from Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables beta-aspartyl-peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables beta-aspartyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
isoaspartyl dipeptidase
NP_418748.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4558354..4559526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418748.1 isoaspartyl dipeptidase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418748.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376X946
    Conserved Domains (1) summary
    TIGR01975
    Location:9 → 388
    isoAsp_dipep; isoaspartyl dipeptidase IadA
Nucleotide Protein
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