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hyfR DNA-binding transcriptional activator HyfR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948886, updated on 3-Dec-2024

Summary

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Official Symbol
hyfR
Official Full Name
DNA-binding transcriptional activator HyfR
Primary source
ECOCYC:G7308
Locus tag
b2491
See related
ASAP:ABE-0008204
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2487
Summary
HyfR , "hydrogenase four regulator," controls the expression of genes responsible for the proton-translocating formate hydrogenase system and for formate transport under anaerobiosis, low pH, and post-exponential growth conditions . [More information is available at EcoCyc: G7308].
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Genomic context

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Sequence:
NC_000913.3 (2611900..2613912)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene hydrogenase 4 component H Neighboring gene hydrogenase 4 catalytic subunit HyfI Neighboring gene putative hydrogenase 4 assembly protein Neighboring gene formate channel FocB Neighboring gene putative transporter YfgO

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Copper (II) ions affect Escherichia coli membrane vesicles' SH-groups and a disulfide-dithiol interchange between membrane proteins. Kirakosyan G, et al. Cell Biochem Biophys, 2008. PMID 18458828
  2. Dissecting the roles of Escherichia coli hydrogenases in biohydrogen production. Redwood MD, et al. FEMS Microbiol Lett, 2008 Jan. PMID 17995952
  3. Expression and regulation of a silent operon, hyf, coding for hydrogenase 4 isoenzyme in Escherichia coli. Self WT, et al. J Bacteriol, 2004 Jan. PMID 14702328, Free PMC Article
  4. A 12-cistron Escherichia coli operon (hyf) encoding a putative proton-translocating formate hydrogenlyase system. Andrews SC, et al. Microbiology (Reading), 1997 Nov. PMID 9387241
  5. Regulation of the hydrogenase-4 operon of Escherichia coli by the sigma(54)-dependent transcriptional activators FhlA and HyfR. Skibinski DA, et al. J Bacteriol, 2002 Dec. PMID 12426353, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-DNA complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
DNA-binding transcriptional activator HyfR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2611900..2613912
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416986.4 DNA-binding transcriptional activator HyfR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416986.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A831GQH7
    Conserved Domains (1) summary
    COG3604
    Location:118 → 669
    FhlA; Transcriptional regulator containing GAF, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms]
Nucleotide Protein
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