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proQ RNA chaperone ProQ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948950, updated on 17-Dec-2024

Summary

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Official Symbol
proQ
Official Full Name
RNA chaperone ProQ
Primary source
ECOCYC:EG12866
Locus tag
b1831
See related
ASAP:ABE-0006092
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1830; yebJ; yobE; yoeC
Summary
An uncharacterized interaction with ProQ is important for activation of ProP as proQ deficient mutants have significantly reduced ProP activity . [More information is available at EcoCyc: EG12866].
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Genomic context

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Sequence:
NC_000913.3 (1914836..1915534, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protease HtpX Neighboring gene tail-specific protease Neighboring gene free methionine-(R)-sulfoxide reductase Neighboring gene intermembrane transport protein LetA Neighboring gene lipophilic envelope spanning tunnel

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Determinants of RNA recognition by the FinO domain of the Escherichia coli ProQ protein. Stein EM, et al. Nucleic Acids Res, 2020 Jul 27. PMID 32542384, Free PMC Article
  2. Genetic identification of the functional surface for RNA binding by Escherichia coli ProQ. Pandey S, et al. Nucleic Acids Res, 2020 May 7. PMID 32170306, Free PMC Article
  3. A ProQ/FinO family protein involved in plasmid copy number control favours fitness of bacteria carrying mcr-1-bearing IncI2 plasmids. Yang J, et al. Nucleic Acids Res, 2021 Apr 19. PMID 33721023, Free PMC Article
  4. Structure of the Escherichia coli ProQ RNA-binding protein. Gonzalez GM, et al. RNA, 2017 May. PMID 28193673, Free PMC Article
  5. Analysis and expansion of the role of the Escherichia coli protein ProQ. Sheidy DT, et al. PLoS One, 2013. PMID 24205389, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A ProQ/FinO family protein involved in plasmid copy number control favours fitness of bacteria carrying mcr-1-bearing IncI2 plasmids.
    Title: A ProQ/FinO family protein involved in plasmid copy number control favours fitness of bacteria carrying mcr-1-bearing IncI2 plasmids.
  2. Determinants of RNA recognition by the FinO domain of the Escherichia coli ProQ protein.
    Title: Determinants of RNA recognition by the FinO domain of the Escherichia coli ProQ protein.
  3. Identification of a group of highly conserved residues on ProQ's N-terminal domain (NTD) as the primary face for in vivo recognition of two RNAs. Authors propose that the NTD structure serves as an electrostatic scaffold to recognize the shape of an RNA duplex.
    Title: Genetic identification of the functional surface for RNA binding by Escherichia coli ProQ.
  4. ProQ targets sRNAs and mRNA 30 UTRs primarily through a structural code and to stabilize some mRNAs by counteracting 30 exoribonuclease activity.
    Title: Global Maps of ProQ Binding In Vivo Reveal Target Recognition via RNA Structure and Stability Control at mRNA 3' Ends.
  5. the data suggest how the FinO, Tudor, and linker domains of ProQ cooperate to recognize complex RNA structures
    Title: Structure of the Escherichia coli ProQ RNA-binding protein.
  6. ProQ and Prc deficiencies lowered the ProP activity of bacteria cultivated at moderate salinity by approximately 70% and 30%, respectively, but did not affect other osmoregulatory functions.
    Title: Salinity-dependent impacts of ProQ, Prc, and Spr deficiencies on Escherichia coli cell structure.
  7. Limited tryptic proteolysis of ProQ revealed protease resistant fragments corresponding to predicted N-terminal & C-terminal domains. N-terminal domain was predominantly alpha-helical, the C-terminal domain was predominantly beta-sheet, as predicted.
    Title: Structural and functional analysis of ProQ: an osmoregulatory protein of Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA strand annealing activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA strand annealing activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA strand annealing activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA strand-exchange activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA strand-exchange activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA strand-exchange activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular hyperosmotic salinity response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in osmosensory signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of proline import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in post-transcriptional regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within post-transcriptional regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-transcriptional regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within single-species biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
RNA chaperone ProQ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1914836..1915534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_026161.1 RNA chaperone ProQ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for YP_026161.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AI35
    Conserved Domains (1) summary
    PRK04950
    Location:1 → 232
    PRK04950; ProP expression regulator; Provisional
Nucleotide Protein
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