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rcsC histidine kinase RcsC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 948993, updated on 3-Dec-2024

Summary

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Official Symbol
rcsC
Official Full Name
histidine kinase RcsC
Primary source
ECOCYC:EG10822
Locus tag
b2218
See related
ASAP:ABE-0007336
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2211
Summary
RcsC belongs to the phophorelay system RcsC/RcsD/RcsB , and is involved in the regulation of the synthesis of colanic acid capsule and motility . [More information is available at EcoCyc: EG10822].
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Genomic context

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Sequence:
NC_000913.3 (2317027..2319876, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene RcsD phosphotransferase Neighboring gene DNA-binding transcriptional activator RcsB Neighboring gene sensor histidine kinase AtoS Neighboring gene DNA-binding transcriptional activator/ornithine decarboxylase inhibitor AtoC Neighboring gene acetyl-CoA:acetoacetyl-CoA transferase subunit alpha Neighboring gene acetyl-CoA:acetoacetyl-CoA transferase subunit beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Complex Rcs Regulatory Cascade. Wall E, et al. Annu Rev Microbiol, 2018 Sep 8. PMID 29897834
  2. Genetic analysis of the RcsC sensor kinase from Escherichia coli K-12. Clarke DJ, et al. J Bacteriol, 2002 Feb. PMID 11807084, Free PMC Article
  3. Comparative functional analysis of the RcsC sensor kinase from different Enterobacteriaceae. Huang YH, et al. FEMS Microbiol Lett, 2009 Apr. PMID 19260968
  4. NMR assignment of 1H, 13C and 15N resonances of the truncated Escherichia coli RcsC (700-949), including the phosphoreceiver domain. Rogov VV, et al. J Biomol NMR, 2007 Jun. PMID 17036162
  5. TerF, the sixth identified replication arrest site in Escherichia coli, is located within the rcsC gene. Sharma B, et al. J Bacteriol, 1992 Dec. PMID 1447156, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RcsF also interacts with the periplasmic domain of the innermembrane-localized histidine kinase RcsC.
    Title: Role of the inner-membrane histidine kinase RcsC and outer-membrane lipoprotein RcsF in the activation of the Rcs phosphorelay signal transduction system in Escherichia coli.
  2. a number of signals that lead to activation of the phosphorelay require both RcsF and RcsC
    Title: Role of RcsF in signaling to the Rcs phosphorelay pathway in Escherichia coli.
  3. Results describe the solution structure of the RcsC C terminus, possessing a phosphoreceiver domain (RcsC-PR) and a region previously described as a long linker between the histidine kinase domain of RcsC (RcsC-HK) and the RcsC-PR.
    Title: A new structural domain in the Escherichia coli RcsC hybrid sensor kinase connects histidine kinase and phosphoreceiver domains.
  4. RcsB and RcsC inversely regulated the timing of flagellar biogenesis
    Title: Acetyl phosphate-sensitive regulation of flagellar biogenesis and capsular biosynthesis depends on the Rcs phosphorelay.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity ISM
Inferred from Sequence Model
more info
 PubMed 
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein histidine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphorelay signal transduction system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within single-species biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
histidine kinase RcsC
NP_416722.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2317027..2319876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416722.2 histidine kinase RcsC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416722.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A895NUG4
    Conserved Domains (1) summary
    PRK10841
    Location:24 → 947
    PRK10841; two-component system sensor histidine kinase RcsC
Nucleotide Protein
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