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idi isopentenyl-diphosphate Delta-isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949020, updated on 3-Dec-2024

Summary

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Official Symbol
idi
Official Full Name
isopentenyl-diphosphate Delta-isomerase
Primary source
ECOCYC:G7508
Locus tag
b2889
See related
ASAP:ABE-0009484
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2884; ygfV
Summary
The idi gene is nonessential. [More information is available at EcoGene: EG13072]. Isopentenyl diphosphate (IPP) isomerase (Idi) catalyzes the reversible isomerization of isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP), a key step in the biosynthesis of isoprenoids. [More information is available at EcoCyc: G7508].
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Genomic context

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Sequence:
NC_000913.3 (3033065..3033613)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene urate:H(+) symporter Neighboring gene uncharacterized protein YqfG Neighboring gene protein YqfH Neighboring gene lysine--tRNA ligase Neighboring gene peptide chain release factor RF2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Catalytic mechanism of Escherichia coli isopentenyl diphosphate isomerase involves Cys-67, Glu-116, and Tyr-104 as suggested by crystal structures of complexes with transition state analogues and irreversible inhibitors. Wouters J, et al. J Biol Chem, 2003 Apr 4. PMID 12540835
  2. Primary neuroendocrine carcinoma of the skin arising from the post aural region. Kacker A, et al. J Laryngol Otol, 1992 Mar. PMID 1564387
  3. Escherichia coli open reading frame 696 is idi, a nonessential gene encoding isopentenyl diphosphate isomerase. Hahn FM, et al. J Bacteriol, 1999 Aug. PMID 10419945, Free PMC Article
  4. Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase. Durbecq V, et al. EMBO J, 2001 Apr 2. PMID 11285217, Free PMC Article
  5. Structural genomics: an approach to the protein folding problem. Montelione GT. Proc Natl Acad Sci U S A, 2001 Nov 20. PMID 11717420, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the importance of residue Tyr-104 for proper folding of Escherichia coli type I IPP isomerase
    Title: Structural role for Tyr-104 in Escherichia coli isopentenyl-diphosphate isomerase: site-directed mutagenesis, enzymology, and protein crystallography.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables isopentenyl-diphosphate delta-isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isopentenyl-diphosphate delta-isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in dimethylallyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within isoprenoid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
isopentenyl-diphosphate Delta-isomerase
NP_417365.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3033065..3033613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417365.1 isopentenyl-diphosphate Delta-isomerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417365.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6D0IDY7
    Conserved Domains (1) summary
    PRK03759
    Location:1 → 180
    PRK03759; isopentenyl-diphosphate Delta-isomerase
Nucleotide Protein
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Gene LinkOut

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