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xanQ xanthine:H(+) symporter XanQ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949075, updated on 17-Dec-2024

Summary

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Official Symbol
xanQ
Official Full Name
xanthine:H(+) symporter XanQ
Primary source
ECOCYC:G7501
Locus tag
b2882
See related
ASAP:ABE-0009463
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2878; ygfO
Summary
The YgfO protein is a member of the NCS2 family of nucleobase transporters. [More information is available at EcoCyc: G7501].
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Genomic context

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Sequence:
NC_000913.3 (3024351..3025751)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative aminohydrolase SsnA Neighboring gene putative oxidoreductase Neighboring gene fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit and Fe-S binding subunit Neighboring gene guanine deaminase Neighboring gene guanine/hypoxanthine transporter GhxQ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of conserved NCS2 motifs in the Escherichia coli xanthine permease XanQ. Karena E, et al. Mol Microbiol, 2015 Oct. PMID 26192456
  2. Role of intramembrane polar residues in the YgfO xanthine permease: HIS-31 and ASN-93 are crucial for affinity and specificity, and ASP-304 and GLU-272 are irreplaceable. Karena E, et al. J Biol Chem, 2009 Sep 4. PMID 19581302, Free PMC Article
  3. 2007 annual progress report synopsis of the Center for Structures of Membrane Proteins. Stroud RM, et al. J Struct Funct Genomics, 2009 Apr. PMID 19148774, Free PMC Article
  4. Cysteine-scanning analysis of putative helix XII in the YgfO xanthine permease: ILE-432 and ASN-430 are important. Papakostas K, et al. J Biol Chem, 2008 May 16. PMID 18359771
  5. Cysteine-scanning analysis of the nucleobase-ascorbate transporter signature motif in YgfO permease of Escherichia coli: Gln-324 and Asn-325 are essential, and Ile-329-Val-339 form an alpha-helix. Karatza P, et al. J Biol Chem, 2006 Dec 29. PMID 17077086

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, we present a comprehensive mutagenesis of XanQ based on the identification and Cys-scanning analysis of conserved sequence motifs in this cluster.
    Title: Analysis of conserved NCS2 motifs in the Escherichia coli xanthine permease XanQ.
  2. Ile-432 and Asn-430 of helix XII are crucial for purine uptake and affinity of YgfO, and Asn-430 is probably at the vicinity of the binding site
    Title: Cysteine-scanning analysis of putative helix XII in the YgfO xanthine permease: ILE-432 and ASN-430 are important.
  3. YgfO functions as specific, high-affinity transporter for xanthine, in a PMF-dependent manner. It does not recognize guanine, hypoxanthine, uracil or uric acid.
    Title: Cloning and functional characterization of two bacterial members of the NAT/NCS2 family in Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables nucleobase transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables xanthine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xanthine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xanthine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within xanthine transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
xanthine:H(+) symporter XanQ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3024351..3025751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417358.2 xanthine:H(+) symporter XanQ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417358.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EH79
    Conserved Domains (1) summary
    TIGR00801
    Location:18 → 445
    ncs2; uracil-xanthine permease
Nucleotide Protein
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