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rcnA Ni(2(+))/Co(2(+)) exporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949078, updated on 3-Dec-2024

Summary

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Official Symbol
rcnA
Official Full Name
Ni(2(+))/Co(2(+)) exporter
Primary source
ECOCYC:G7138
Locus tag
b2106
See related
ASAP:ABE-0006968
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2099; yohM
Summary
Induced by nickel or cobalt. [More information is available at EcoGene: EG14071]. RcnA is a membrane-bound efflux system for nickel and cobalt resistance. rcnA mutants showed decreased resistance to nickel and cobalt. [More information is available at EcoCyc: G7138].
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Genomic context

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Sequence:
NC_000913.3 (2185917..2186741)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase Neighboring gene hydroxyethylthiazole kinase Neighboring gene DNA-binding transcriptional repressor RcnR Neighboring gene periplasmic protein involved in nickel/cobalt export Neighboring gene putative fimbrial adhesin YehA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nickel promotes biofilm formation by Escherichia coli K-12 strains that produce curli. Perrin C, et al. Appl Environ Microbiol, 2009 Mar. PMID 19168650, Free PMC Article
  2. The RcnRA (YohLM) system of Escherichia coli: a connection between nickel, cobalt and iron homeostasis. Koch D, et al. Biometals, 2007 Oct. PMID 17120142
  3. The Escherichia coli metallo-regulator RcnR represses rcnA and rcnR transcription through binding on a shared operator site: Insights into regulatory specificity towards nickel and cobalt. Blaha D, et al. Biochimie, 2011 Mar. PMID 21040754
  4. Ni(II) and Co(II) sensing by Escherichia coli RcnR. Iwig JS, et al. J Am Chem Soc, 2008 Jun 18. PMID 18505253, Free PMC Article
  5. Identification of rcnA (yohM), a nickel and cobalt resistance gene in Escherichia coli. Rodrigue A, et al. J Bacteriol, 2005 Apr. PMID 15805538, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables nickel cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nickel cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nickel cation transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cobalt ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular nickel ion homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nickel cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nickel cation transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nickel cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to cobalt ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to cobalt ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to nickel cation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to nickel cation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Ni(2(+))/Co(2(+)) exporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2185917..2186741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416609.1 Ni(2(+))/Co(2(+)) exporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416609.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1V2GFY8, A0AAN3TSF8
    Conserved Domains (1) summary
    PRK10019
    Location:1 → 274
    PRK10019; nickel/cobalt efflux transporter RcnA
Nucleotide Protein
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