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ribF bifunctional riboflavin kinase/FMN adenylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 949129, updated on 17-Dec-2024

Summary

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Official Symbol
ribF
Official Full Name
bifunctional riboflavin kinase/FMN adenylyltransferase
Primary source
ECOCYC:EG11079
Locus tag
b0025
See related
ASAP:ABE-0000091
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0026; yaaC
Summary
The riboflavin kinase is the N-terminal domain; the FAD synthase is the C-terminal domain. [More information is available at EcoGene: EG11079]. It is thought that ribF encodes a bifunctional protein with riboflavin kinase and FMN adenylyltransferase activities. [More information is available at EcoCyc: EG11079].
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Genomic context

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Sequence:
NC_000913.3 (21407..22348)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 30S ribosomal subunit protein S20 Neighboring gene DUF2575 domain-containing protein YaaY Neighboring gene isoleucine--tRNA ligase Neighboring gene lipoprotein signal peptidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of the genes in the Escherichia coli ileS-lsp operon. Analysis of multiple polycistronic mRNAs made in vivo. Miller KW, et al. J Biol Chem, 1987 May 25. PMID 3294831
  2. Cotranscription of the Escherichia coli isoleucyl-tRNA synthetase (ileS) and prolipoprotein signal peptidase (lsp) genes. Fine-structure mapping of the lsp internal promoter. Miller KW, et al. J Biol Chem, 1987 Jan 5. PMID 2432063
  3. Characterization of the ileS-lsp operon in Escherichia coli. Identification of an open reading frame upstream of the ileS gene and potential promoter(s) for the ileS-lsp operon. Kamio Y, et al. J Biol Chem, 1985 May 10. PMID 2985604
  4. From genetic footprinting to antimicrobial drug targets: examples in cofactor biosynthetic pathways. Gerdes SY, et al. J Bacteriol, 2002 Aug. PMID 12142426, Free PMC Article
  5. A genome-based approach for the identification of essential bacterial genes. Arigoni F, et al. Nat Biotechnol, 1998 Sep. PMID 9743119

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables FMN adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables FMN adenylyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables riboflavin kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables riboflavin kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables riboflavin kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in FAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in FMN biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in FMN biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in riboflavin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in riboflavin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bifunctional riboflavin kinase/FMN adenylyltransferase
NP_414566.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    21407..22348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414566.1 bifunctional riboflavin kinase/FMN adenylyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414566.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A836NFS5, A0A8E0FJP9, A0AAN3V3K0, A0AAN4NXY0, A0AAV3H188, A0AAV3IC31
    Conserved Domains (1) summary
    PRK05627
    Location:2 → 309
    PRK05627; bifunctional riboflavin kinase/FAD synthetase
Nucleotide Protein
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