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DZIP3 DAZ interacting zinc finger protein 3 [ Homo sapiens (human) ]

Gene ID: 9666, updated on 27-Nov-2024

Summary

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Official Symbol
DZIP3provided by HGNC
Official Full Name
DAZ interacting zinc finger protein 3provided by HGNC
Primary source
HGNC:HGNC:30938
See related
Ensembl:ENSG00000198919 MIM:608672; AllianceGenome:HGNC:30938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UURF2; PPP1R66; hRUL138
Summary
Enables several functions, including phosphatase binding activity; polyubiquitin modification-dependent protein binding activity; and ubiquitin-protein transferase activity. Involved in protein polyubiquitination. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 21.6), brain (RPKM 12.1) and 21 other tissues See more
Orthologs
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Genomic context

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See DZIP3 in Genome Data Viewer
Location:
3q13.13
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108589510..108694840)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111309763..111415213)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108308569..108413687)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 15 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene cellular inhibitor of PP2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20222 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:108396720-108396891 Neighboring gene uncharacterized LOC105374033 Neighboring gene uncharacterized LOC105374034 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:108462949-108464148

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas. Liang T, et al. Aging (Albany NY), 2020 Nov 21. PMID 33229627, Free PMC Article
  2. RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression. Kolapalli SP, et al. Cancer Res, 2021 Jan 15. PMID 33067265, Free PMC Article
  3. hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase. Kreft SG, et al. J Cell Sci, 2003 Feb 15. PMID 12538761
  4. Novel CARM1-Interacting Protein, DZIP3, Is a Transcriptional Coactivator of Estrogen Receptor-α. Purcell DJ, et al. Mol Endocrinol, 2015 Dec. PMID 26505218, Free PMC Article
  5. Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination. Yoon JH, et al. Nat Commun, 2013. PMID 24326307, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.
    Title: Proteomic analysis of DZIP3 interactome and its role in proliferation and metastasis in gastric cancer cells.
  2. DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas.
    Title: DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas.
  3. RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression.
    Title: RNA-Binding RING E3-Ligase DZIP3/hRUL138 Stabilizes Cyclin D1 to Drive Cell-Cycle and Cancer Progression.
  4. By monoubiquitination of H2A at lysine 119, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TLR activation.
    Title: Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13327, FLJ57977, FLJ58022, FLJ58223, KIAA0675

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase DZIP3
Names
DAZ interacting protein 3, zinc finger
DAZ-interacting protein 3
RING-type E3 ubiquitin transferase DZIP3
RNA-binding RING-H2 protein-ubiquitin ligase
RNA-binding ubiquitin ligase of 138 kDa
UURF2 ubiquitin ligase
human RNA-binding ubiquitin ligase of 138 kDa
protein phosphatase 1, regulatory subunit 66
zinc finger DAZ interacting protein 3
NP_055463.1
XP_005247971.1
XP_005247972.1
XP_005247973.1
XP_005247974.1
XP_005247975.1
XP_005247976.1
XP_016863029.1
XP_047305210.1
XP_047305211.1
XP_047305212.1
XP_047305213.1
XP_047305214.1
XP_054204461.1
XP_054204462.1
XP_054204463.1
XP_054204464.1
XP_054204465.1
XP_054204466.1
XP_054204467.1
XP_054204468.1
XP_054204469.1
XP_054204470.1
XP_054204471.1
XP_054204472.1
XP_054204473.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014648.4 → NP_055463.1  E3 ubiquitin-protein ligase DZIP3

    See identical proteins and their annotated locations for NP_055463.1

    Status: VALIDATED

    Source sequence(s)
    AC092185, AC092693
    Consensus CDS
    CCDS2952.1
    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Related
    ENSP00000355028.3, ENST00000361582.8
    Conserved Domains (2) summary
    cd16460
    Location:1147 → 1188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675 → 856
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    108589510..108694840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247917.4 → XP_005247974.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247974.1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Conserved Domains (2) summary
    cd16460
    Location:1147 → 1188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675 → 856
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_005247914.5 → XP_005247971.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247971.1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Conserved Domains (2) summary
    cd16460
    Location:1147 → 1188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675 → 856
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_047449256.1 → XP_047305212.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

  4. XM_005247918.4 → XP_005247975.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247975.1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Conserved Domains (2) summary
    cd16460
    Location:1147 → 1188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675 → 856
    SMC_N; RecF/RecN/SMC N terminal domain

  5. XM_005247919.5 → XP_005247976.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

    Conserved Domains (2) summary
    pfam12678
    Location:941 → 982
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:942 → 982
    zf-RING_2; Ring finger domain

  6. XM_047449254.1 → XP_047305210.1  E3 ubiquitin-protein ligase DZIP3 isoform X2

  7. XM_047449255.1 → XP_047305211.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

  8. XM_047449257.1 → XP_047305213.1  E3 ubiquitin-protein ligase DZIP3 isoform X5

  9. XM_047449258.1 → XP_047305214.1  E3 ubiquitin-protein ligase DZIP3 isoform X6

    Related
    ENSP00000418115.1, ENST00000479138.5

  10. XM_017007540.2 → XP_016863029.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Conserved Domains (2) summary
    cd16460
    Location:1147 → 1188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675 → 856
    SMC_N; RecF/RecN/SMC N terminal domain

  11. XM_005247916.4 → XP_005247973.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247973.1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Conserved Domains (2) summary
    cd16460
    Location:1147 → 1188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675 → 856
    SMC_N; RecF/RecN/SMC N terminal domain

  12. XM_005247915.4 → XP_005247972.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    See identical proteins and their annotated locations for XP_005247972.1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
    Related
    ENSP00000419981.1, ENST00000463306.1
    Conserved Domains (2) summary
    cd16460
    Location:1147 → 1188
    RING-H2_DZIP3; RING finger, H2 subclass, found in DAZ (deleted in azoospermia)-interacting protein 3 (DZIP3) and similar proteins
    cl25732
    Location:675 → 856
    SMC_N; RecF/RecN/SMC N terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    111309763..111415213
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348490.1 → XP_054204465.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9

  2. XM_054348492.1 → XP_054204467.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9

  3. XM_054348488.1 → XP_054204463.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9

  4. XM_054348496.1 → XP_054204471.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

  5. XM_054348495.1 → XP_054204470.1  E3 ubiquitin-protein ligase DZIP3 isoform X4

  6. XM_054348493.1 → XP_054204468.1  E3 ubiquitin-protein ligase DZIP3 isoform X2

  7. XM_054348494.1 → XP_054204469.1  E3 ubiquitin-protein ligase DZIP3 isoform X3

  8. XM_054348497.1 → XP_054204472.1  E3 ubiquitin-protein ligase DZIP3 isoform X5

  9. XM_054348498.1 → XP_054204473.1  E3 ubiquitin-protein ligase DZIP3 isoform X6

  10. XM_054348489.1 → XP_054204464.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9

  11. XM_054348486.1 → XP_054204461.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9

  12. XM_054348487.1 → XP_054204462.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9

  13. XM_054348491.1 → XP_054204466.1  E3 ubiquitin-protein ligase DZIP3 isoform X1

    UniProtKB/Swiss-Prot
    B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y13, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86Y13.2 GenPept UniProtKB/Swiss-Prot:Q86Y13

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